补肾健脾养血活血法改善血管性认知障碍大鼠行为学障碍的研究  

Study of invigorating kidney and strengthening spleen,nourishing blood and promoting blood method in improving the behavior of rats with vascular cognitive impairment

作　　者：沈双宏[1] 沈晓东 吴同玉[1] 龚德贵[3] 毛敬洁[1] 杜建[1] 

机构地区：[1]福建中医药大学中西医结合研究院,福建福州350108 [2]黑龙江省农垦第二医院中医科,黑龙江佳木斯154007 [3]福建省第二人民医院康复科,福建福州350003

出　　处：《中国医药导报》2011年第35期24-26,共3页China Medical Herald

基　　金：福建省科技厅自然科学基金项目(2007j0339);福建重点建设高等学校重点学科研究基金项目(ZX08003);福建省中西医结合老年性疾病重点实验室开放课题.陈可冀中西医结合发展基金(2008J004-21;CKJ2008058)

摘　　要：目的:观察补肾健脾养血活血法对血管性认知障碍(VCI)大鼠行为学的影响。方法:造模前随机选取10只大鼠为假手术组,其余大鼠采用反复夹闭双侧颈总动脉结合腹腔注射硝普钠降低血压改良法建立VCI大鼠模型,造模成功后将其随机分为康欣胶囊复方组(复方组)、康欣胶囊简化方组(简方组)、西药对照组、模型组,每组10只。经过3周药物干预后,通过Morris水迷宫观察模型大鼠逃避潜伏期和穿越平台次数,测试其学习记忆能力。结果:与模型组比较,复方组、简方组、西药对照组逃避潜伏期明显缩短[(14.57±3.99)、(16.93±2.54)、(18.42±7.35)s],穿越平台区域的次数明显增多[(6.90±1.86)、(7.20±1.75)、(6.10±2.46)次],差异有统计学意义(P<0.05)。结论:补肾健脾养血活血立法的康欣胶囊能明显改善VCI大鼠的行为学障碍。Objective： To observe the impact of invigorating kidney and strengthening spleen,nourishing blood and promoting blood method on behavior of rats with vascular cognitive impairment（VCI）.Methods： 10 rats were chosen randomly as sham operation group before operation,the left rats were caused by the reformed method of lowering blood pressure by clipping two sides of total artery in neck repeatedly combined with Sodium Nitrate of intraperitoneal injection to make vascular cognitive impairment model,which were randomly divided into four groups,namely Kangxin capsule compound group（compound group）,Kangxin capsule simplified group（simplified group）,western medicine control group and model group,with 10 rats in each group.After treatment for 3 weeks,the escape latency,the times of crossing platform and the learning and memory capacity of the model rats were observed by morris water maze.Results： Compared with model group,the escape latency of rats in Kangxin capsule group,compound group,simplified group and western medicine control group were shortened obviously [（14.57±3.99）,（16.93±2.54）,（18.42±7.35） s] and the times of crossing platform were increased obviously [（6.90±1.86）,（7.20±1.75）,（6.10±2.46） times],the differences were significant（P0.05）.Conclusion： Kangxin capsule made by invigorating kidney and strengthening spleen,nourishing blood and promoting blood can improve behavior of VCI model rats.

关 键 词：血管性认知障碍 行为学障碍 康欣胶囊 MORRIS水迷宫 

分 类 号：R743[医药卫生—神经病学与精神病学]