胰腺癌患者氩氦刀冷冻治疗前后血清CA242和TSGF检测的临床意义  

Clinical significance of determination of serum CA242 and TSGF levels before and after argon-helium cryosurgery in patients with pancreatic cancer

作　　者：周刚 邱大卫 牛立志 何丽华 徐克成 

机构地区：[1]中国科学院广州生物医药与健康研究院附属复大医院,广州510310 [2]广州市复大肿瘤医院,510305

出　　处：《国际检验医学杂志》2011年第19期2187-2188,2191,共3页International Journal of Laboratory Medicine

基　　金：广东省医学科学技术研究基金项目(WSTJJ20090401440106196602154756)

摘　　要：目的探讨胰腺癌患者氩氦刀冷冻消融治疗前后血清糖类抗原242(CA242)与恶性肿瘤特异性生长因子(TSGF)的水平变化及其临床意义。方法采用电化学发光和生化法对15例胰腺癌患者冷冻消融治疗前后血清CA242和TSGF水平进行测定,并与15例健康者作比较。结果胰腺癌患者在治疗前后血清CA242和TSGF的水平均显著高于健康者(P<0.01);患者治疗后血清CA242和TSGF水平均显著低于治疗前(P<0.05);患者治疗前后CA242的水平均与性别、临床分期及肝转移有关(P<0.05)。结论氩氦刀冷冻消融治疗后可降低胰腺癌患者血清CA242和TSGF水平,CA242和TSGF可作为胰腺癌诊断、疗效评估的重要指标,CA242对胰腺癌的预后观察有重要的临床意义。Objective To study the clinical significance of alteration of serum carbohydrate antigen 242 （CA242）and malignant tumor specific growth factor （TSGF）levels after argon-helium cryosurgery in patients with pancreatic cancer. Methods Serum CA242 and TSGF levels were measured in 15 patients with pancreatic cancer before and after argon helium cryosurgery,as well as in 15 controls. Results Serum CA242 and TSGF levels of pancreatic cancer patients before and after operation were significantly higher than controls（P^0.01）. Both serum CA242 and TSGF levels of preoperative patients were significantly higher than postop- erative patients（P^0.05）. The serum levels of CA242 was associated with the sex,clinical stage and liver metastasis for both pre- operative and postoperative patients. Conclusion Argon helium cryosurgery could be able to decrease the serum CA242 and TSGF levels. CA242 and TSGF can be used as indicator for the diagnosis and therapy evaluation in patients with pancreatic cancer and CA242 play a important role in the prognosis of pancreatic cancer.

关 键 词：胰腺肿瘤 糖类抗原242 恶性肿瘤特异性生长因子 氩氦刀冷冻消融 

分 类 号：R735.9[医药卫生—肿瘤]