涎腺粘液表皮样癌COX-2表达与肿瘤血管生成的研究  

Study of COX-2 expression and angiogenesis in salivary glands mucoepidermoid carcinoma

作　　者：于肖鹏[1] 时立芬[1] 李晓光[1] 

机构地区：[1]泰山医学院附属泰山医院口腔科,山东泰安271000

出　　处：《泰山医学院学报》2011年第10期727-730,共4页Journal of Taishan Medical College

摘　　要：目的探讨环氧化酶-2(Cycloxygenase-2,COX-2)表达与涎腺粘液表皮样癌(mucoepidermoid carcinoma,MEG)血管生成的关系。方法免疫组化检测MEG中COX-2、诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、血管内皮生长因子(vascular endothelial growth factor,VEGF)表达,并测定肿瘤微血管密度(microvessel density,MVD)。结果 MEG中COX-2表达与VEGF、iNOS表达密切相关(P<0.01,P<0.05)。MEG中COX-2表达阳性组和阴性组MVD有显著差异(P<0.05)。结论 MEG中COX-2表达和肿瘤血管生成有关,iNOS和VEGF可能参与COX-2对肿瘤血管生成的促进作用。Objective： To explore the relationships between Cycloxygenase -2 （ COX -2 ） expression and angiogenesis in salivary glands mucoepidermoid carcinoma（ MEG）. Methods： The COX- 2 expression, inducible nitric oxide synthase（ iNOS） and vascular endothelial growth factor（ VEGF） expression, microvessel density （ MVD ） were evalulated by immunohistochemical method. Results ： The expressions of COX - 2 and iNOS, VEGF in MEG were significantly positively correlated （ P 〈 0.01, P 〈 0.05 ）. There was significant difference in MVD between COX - 2 postive MEG and negative ones （ P 〈 0. 05 ）. Conclusion： The present findings suggest that there is some link between COX -2 and angiogenesis in MEG, partly attributing to the effect of VEGF and iNOS.

关 键 词：粘液表皮样癌 环氧化酶 血管生成 血管内皮生长因子 诱导型一氧化氮合酶 

分 类 号：R739.8[医药卫生—肿瘤]