弥漫大B细胞淋巴瘤中Bcl-2基因表达的临床意义  

The clinical significance of gene expression Bcl-2 in diffuse large B cell lymphoma

作　　者：朱锋[1] 周丽[1] 

机构地区：[1]泰山医学院附属医院血液科,山东泰安271000

出　　处：《泰山医学院学报》2011年第10期758-760,共3页Journal of Taishan Medical College

摘　　要：目的探讨Bcl-2基因表达在弥漫大B细胞淋巴瘤(DLBCL)中表达的临床意义。方法利用免疫组织化学方法检测Bcl-2在弥漫大B细胞淋巴瘤细胞中的表达,研究它的表达与弥漫大B细胞淋巴瘤临床分期、全身症状及治疗效果的关系。结果弥漫大B细胞淋巴瘤临床分期为III/IV期、疗效差、全身症状明显者,Bcl-2表达阳性率高。结论检测Bcl-2在弥漫大B细胞淋巴瘤中的表达对评估弥漫大B细胞淋巴瘤分期、疗效及不良临床过程有一定意义,Bcl-2的高表达可以作为弥漫大B细胞淋巴瘤不良临床特征、疗效差的标志之一。Objective： To investigate the clinical significance of gene expression Bcl - 2 in diffuse large B cell lymphoma. Methods ： The expression of Bcl - 2 was detected in diffuse large B cell lymphoma by immunohistochemistry and the relationships between the genetic expression of Bcl - 2 and the clinical stages, general symptoms and therapeutic effects were studied. Results ： The clinical stages of diffuse large B cell lymphoma were Stage Ⅲ/Ⅳ, and the group with poor treatment and the group with obvious general symptoms and the positive rate of Bcl - 2 expression were high. Results ： The detection of the expression of Bcl - 2 in diffuse large B cell lymphoma had significance in the assessment of stages, therapeutic effects and the adverse clinical process. Conclusion： The high expression of Bcl - 2 can be the indications of adverse clinical feature, poor treatment and poor prognosis.

关 键 词：弥漫大B细胞淋巴瘤 BCL-2基因 表达 

分 类 号：R733.1[医药卫生—肿瘤]