Pd（OAc）2-Catalyzed Tandem Reactions for the Synthesis of Indol-3-yl Substituted 1H-Isochromenes and 1,2-Dihydroisoquinolines  

作　　者：王欢 韩秀玲 陆熙炎 

机构地区：[1]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2011年第12期2611-2618,共8页中国化学（英文版）

基　　金：Project supported by the National Basic Research Program of China （No. 2009CB825300） and the Natural Science Foundation of China （Nos. 20732005, 20872158）.

摘　　要：A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd（II） species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.A Pd（II） catalyzed tandem reaction of o-alkynylbenzaldehydes or o-alkynylbenzaldimines with substituted indoles initiated by the intermolecular addition of indoles to the carbonyl or imine group followed by the nucleopalladation of an intramolecular alkyne and quenching the carbon-palladium bond by protonolysis to regenerate the Pd（II） species was developed. The reaction can be carried out under mild conditions without the necessity of a redox system.

关 键 词：ALKYNE carbonyl group IMINE INDOLE Pd（OAc）2 

分 类 号：O623.413[理学—有机化学] TQ225.241[理学—化学]