Synthesis of Fluoroalkylated Allylic-β-hydroxyesters and Fluoroalkylated ,β,γ-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate  

作　　者：方向 熊英 王琼 赵敏 吴范宏 

机构地区：[1]Laboratory for Advanced Material and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China [2]School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 200235, China

出　　处：《Chinese Journal of Chemistry》2011年第12期2669-2674,共6页中国化学（英文版）

基　　金：project supported by the National Natural Science Foundation of China （NNSFC） （Nos. 20972050, 21172148）.

摘　　要：A sequential transformation of fluoroalkylated adducts obtained from ethyl 3-hydroxy-4-pentenoate with fluorinated iodides was reported. The dehydrohalogenation of adducts was favored to give fluoroalkylated unsaturated β-hydroxy esters in the presence of triethylamine. And intramolecular SN42 reaction products, fluoroalkylated β,γ-epoxy esters, were obtained in 10% aqueous sodium carbonate solution.A sequential transformation of fluoroalkylated adducts obtained from ethyl 3-hydroxy-4-pentenoate with fluorinated iodides was reported. The dehydrohalogenation of adducts was favored to give fluoroalkylated unsaturated β-hydroxy esters in the presence of triethylamine. And intramolecular SN42 reaction products, fluoroalkylated β,γ-epoxy esters, were obtained in 10% aqueous sodium carbonate solution.

关 键 词：ethyl 3-hydroxy-4-pentenoate fluoroalkylated allylic-β-hydroxyesters fluoroalkylated β γ-epoxy esters 

分 类 号：TQ225.4[化学工程—有机化工] S379.5[农业科学—农产品加工]