Polyfluoroalkylation of 2-Aminothiazoles： Unexpected sp3 C CI Substitution under Mild Conditions  

作　　者：齐卿卿 沈其龙 吕龙 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2011年第12期2681-2683,共3页中国化学（英文版）

基　　金：Project supported by special Fund for Agro-scientific Research in the Public Interest （No. 201103007）, the National Key Technologies R＆D Program （No. 2011BAE06B05）, National Basic Research Program of China （No. 2010CB126103）, the Key Program of National Natural Science Foundation of China （No. 21032006） and SIOC startup fund.

摘　　要：An efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives was described. Specifically, a di-polyfluoroalkylated derivative was produced when 2-amino-4-chloromethylthiazole was reacted with perfluoroalkyl iodides under very mild conditions.An efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives was described. Specifically, a di-polyfluoroalkylated derivative was produced when 2-amino-4-chloromethylthiazole was reacted with perfluoroalkyl iodides under very mild conditions.

关 键 词：POLYFLUOROALKYLATION 2-AMINOTHIAZOLE dipolyfluoroalkylation SULFINATODEHALOGENATION 

分 类 号：TQ522.1[化学工程—煤化学工程] TP316.7[自动化与计算机技术—计算机软件与理论]