青刺果黄酮对糖尿病小鼠肺病理变化的影响  

The effects of flavonoids from Prinsepia utilis Royle on the pathologic changes of lung in the diabetic mice

作　　者：吕程[1,2] 贾仁勇[1,2] 殷中琼[1,2] 吴小兰[1] 张雅雪[1] 

机构地区：[1]四川农业大学动物医学院,四川雅安625014 [2]四川农业大学动物疫病与人类健康四川省重点实验室,四川雅安625014

出　　处：《华西药学杂志》2011年第6期540-542,共3页West China Journal of Pharmaceutical Sciences

基　　金：四川农业大学引进人才项目;教育部<长江学者和创新团队发展计划>创新团队项目(IRTO848)

摘　　要：目的观察青刺果黄酮(FPR)对糖尿病小鼠肺病变的影响。方法用四氧嘧啶建立糖尿病小鼠模型,并ig给予300mg.kg-1FPR治疗,连续4周。分别于2、4周末于各组随机抽取4只小鼠宰杀,取出肺脏。肺组织用石蜡切片、HE和Gomori染色、显微镜观测。结果糖尿病小鼠的肺弥漫性出血,肺泡腔缩小,肺泡壁增厚,支气管周围的纤维细胞增生和淋巴细胞浸润,肺间质、支气管周围网状纤维和胶原纤维的含量增加。FPR治疗组小鼠的肺出血得到缓解,肺泡腔增大,肺泡壁基本恢复正常,肺间质、支气管周围有少量的网状纤维和胶原纤维。结论 FPR能明显减轻糖尿病小鼠肺的病理变化,有效延缓糖尿病引起的肺损伤。OBJECTIVE To observe the effects of flavonoids from Prinsepia utilis Royle on the pathologic changes of lung in diabetic mice.METHODS Diabetic mice induced by alloxan were given flavonoids from Prinsepia utilis Royle orally 300 mg·kg-1 each day for four weeks.Two weeks and four weeks later four mice in each group were randomly sacrificed,and the lungs were taken out and fixed with 4% polyoxym ethylene.The lung tissue was embedded with paraffin and the sections were tained with hematoxylin and eosin（HE） and Gomori,then observed with microscopy.RESULTS In the model control group,the lung developed to the diffuse hemorrhages,the alveolar space was deflated,the alverolar walls were thickened,the fibrocytes proliferated and lymphocytes infiltrated in the surrounding of bronchi,the amount of reticular fiber and collagen fiber increased in lung interstitium and in the surrounding of bronchi.In the treatment group,the pulmonary haemorrhage was reliefed,the alveolar space was augmented,the alverolar walls were almost recovered to a normal state.Little reticular fiber and collagen fiber appeared in lung interstitium and in the surrounding of bronchi.CONCLUSION Flavonoids from Prinsepia utilis Royle can relieve the changes of pathology of pulmonary tissue,and delay the progression of injure of pulmonary tissue induced by diabetes mellitus.

关 键 词：黄酮 青刺果 糖尿病 肺病变 小鼠 

分 类 号：R96[医药卫生—药理学]