乳腺癌中血管内皮生长因子和基质金属蛋白酶-9的表达与淋巴结转移的关系  

Relationship between expression of VEGF and MMP-9 in breast carcinoma and lymph node metastasis

作　　者：瞿峰[1] 梁爽[2] 刘惠民[2] 赵琰龙[1] 时志民[2] 

机构地区：[1]河北工程大学附属医院,056002 [2]河北工程大学医学院

出　　处：《中国误诊学杂志》2011年第34期8329-8330,共2页Chinese Journal of Misdiagnostics

摘　　要：目的检测血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在乳腺癌中的表达情况,研究两者与淋巴结转移的关系。方法采用免疫组化SP法检测92例乳腺浸润癌中VEGF、MMP-9的表达情况。结果 VEGF蛋白在对照组和乳腺癌组中的阳性表达率分别为6.7%(3/45)和90.2%(83/92),且VEGF在淋巴结转移组中的阳性表达率(53/55)明显高于无淋巴结转移组(P<0.05)。MMP-9蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为0(0/45)和92.4%(85/92),而且MMP-9在淋巴结转移组中的阳性表达率(54/55)明显高于无淋巴结转移组(P<0.05)。结论 VEGF、MMP-9蛋白在乳腺癌组织中高表达,且均与淋巴结转移有关(P<0.05),两者可能在乳腺癌的远处转移中起协同作用。Objective To detect the expression of VEGF and MMP-9 in invasive breast carcinoma,and explore their relationship with lymph node metastasis.Methods The expression of VEGF and MMP-9 was studied in 92 cases of invasive breast carcinoma by SP immunohistochemistry.Results The positive expression of VEGF protein in control group and breast carcinoma group was 6.7%（3/45）,90.2%（83/92） respectively,and the positive rate of VEGF in the lymph node metastasis（53/55） was significantly higher than those without lymph node metastasis（P0.05）.The positive expression of MMP-9 protein in control group and breast carcinoma group was 0（0/45）,92.4%（85/92） respectively,and the positive rate of MMP-9 in the lymph node metastasis（54/55） was significantly higher than those without lymph node metastasis（P0.05）.Conclusion VEGF and MMP-9 protein are highly expressed in breast carcinoma,and are all related with lymph node metastasis（P0.05）,VEGF and MMP-9 may become synergistic action during lymph node metastasis of breast carcinoma.

关 键 词：乳腺肿瘤/代谢 血管内皮生长因子类/代谢 基质金属蛋白酶9/代谢 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]