联检CEA、CA_(125)在肺癌并胸腔积液中的诊断价值  

Clinial evaluation of CA_(125) and CEA of pleural effusion in patients with lung carcinoma

作　　者：戴斌[1] 黄翠萍[1] 

机构地区：[1]湖北省咸宁学院医学院内科,437100

出　　处：《中国误诊学杂志》2011年第34期8340-8341,共2页Chinese Journal of Misdiagnostics

摘　　要：目的探讨CEA、CA125在良、恶性胸腔积液鉴别诊断中的价值。方法对46例恶性胸腔积液、44例良性胸腔积液患者于治疗前分别抽取血清及第1次胸腔积液标本进行CA125、CEA测定。结果恶性胸腔积液组血清和胸腔积液CA125、CEA测定值高于良性胸腔积液组(P<0.01)。在胸腔积液中,CA125假阴性56.5%(26/46),假阳性86.4%(38/44);CEA假阴性67.4%(31/46),假阳性81.8%(36/44);CEA和CA125联合检测假阴性69.6%,假阳性90.9%。结论胸腔积液CA125和CEA联合检测有利于良恶性胸腔积液的鉴别,且比血清中更具有临床价值。Objective To evaluate the value of CA125 and CEA in the diagnosis and differentiation between the benign and malignant pleural effusion.Method The measurement of CA125,CEA in blood and the first pleural effusion specimen were performed in cases of malignant pleural effusion and cases of benign pleural effusion before treatment,the results of the two groups were compared.Results The level of CA125,CEA in the blood and malignant pleural effusion patients was higher than that in the benign pleural effusion paients（P0.01）.In the pleural effusion,false negative and false positive of the CA125 were 56.5%（26/46） and 86.4%（38/44） respectively.False negative and false positive of the CEA were 67.4%（31/46） and 81.8%（36/44） respectively.False negative and false positive of the CA125 and CEA in combination were 69.6% and 90.9% respeitively.Conclusions The value of the CA125 and CEA in combination diagnose malignant pleural effusion is more important than those used separately,and more clinical value1 than that in the Serum.

关 键 词：CA-125抗原/诊断应用 癌胚抗原/诊断应用 肺肿瘤/并发症/诊断 胸腔积液/并发症/诊断 

分 类 号：R734.2[医药卫生—肿瘤] R561.3[医药卫生—临床医学]