嗅神经母细胞瘤15例治疗分析  

Treatment of 15 Patients with Olfactery Neuroblastoma

作　　者：罗定泰[1] 胡心传[1] 皮正超[1] 

机构地区：[1]湖北省肿瘤医院

出　　处：《河南肿瘤学杂志》1999年第6期456-457,共2页Henan Journal of Oncology

摘　　要：目的　探讨放射治疗在嗅神经母细胞瘤中的地位和疗效。方法　我院于１９７８ ～１９９７ 年间共收治１５ 例嗅神经母细胞瘤，均经病理证实，１４ 例发生于鼻腔，１ 例发生于颅内；年龄１７ ～６８ 岁，男性８ 例，女性７例。根据Ｋａｄｉｓｈ 分期，Ａ期２ 例，Ｂ期４ 例，Ｃ期８ 例，１ 例未分期，１０ 例手术加放疗，５ 例单纯放疗，２ 例合并化疗，治疗后有８ 例局部复发，２ 例远处转移，大部分病人放疗５０ ～６０Ｇｙ。结果　本组５ 年生存为４０％ ，Ａ期病人单纯放疗有很好的疗效，放疗剂量高的较剂量低的疗效要好。结论　局部复发为治疗失败的主要原因，晚期病人应以手术加放疗为主的综合治疗为有效治疗手段。Objective To evaluate the role of radiotherapy in the treatment of olfactory neuroblastoma.Methods From 1978 to 1997,15 patients with olfactory neuroblastoma were treated inclading 14 in nasal cavity, 1 in the cribritorm plate.The patients′ age ranged from 17 to 68.Seven patients were female and eight male,According to Kadish staging,2 patients had stage A 4 stage B,8 stage C and 1 unstanded lesion.5 patients were treated by radiotherapy only 10 patients with postoperative irradiation and 2 in combination with chemotherapy.Eight patients had local recurence and 2 patients had distance metastasis after radiotherapy.Results The 5 year survival rate was 40%.Patients with stage A can cured by radiotherapy alone.Conclusions Radiotherapy or operation is effective for early lesions while combined treatment is necessary for pationts with advanced olfactery neuroblastoma. [

关 键 词：嗅神经母细胞瘤 手术加放疗 放射疗法 治疗 

分 类 号：R739.620.5[医药卫生—肿瘤]