正常人胚早期绒毛膜及蜕膜组织中层粘连蛋白和纤维粘连蛋白的定位研究  

EXPRESSION OF LAMININ AND FIBRONECTIN IN NORMAL HUMAN CHORION AND DECIDUAL TISSUE

作　　者：王强[1] 高英茂[2] 张金萍[1] 张秀云[3] 崔运河[1] 孙秀丽[1] 

机构地区：[1]济宁医学院组织学与胚胎学教研室 [2]山东医科大学 [3]济宁医学院附属医院

出　　处：《济宁医学院学报》1999年第4期14-16,共3页Journal of Jining Medical University

摘　　要：目的　探讨层粘连蛋白和纤维粘连蛋白在绒毛发生、发育，胎盘的形成、构建过程中的作用。方法　采用免疫组织化学方法观察层粘连蛋白和纤维粘连蛋白在正常人胚早期绒毛膜和蜕膜组织中的分布。结果　层粘连蛋白在正常绒毛上皮基膜、毛细血管内皮基膜、蜕膜细胞及细胞间质内呈阳性表达。纤维粘连蛋白在绒毛间质、毛细血管内皮基膜、蜕膜细胞及细胞间质内呈阳性表达。结论　层粘连蛋白和纤维粘连蛋白是滋养细胞对子宫内膜粘附和侵蚀的重要生物学因素，在绒毛的发生、发育，胎盘形成和构建过程中均起重要作用。Objective To explore the effects of LN and FN in the process of development of villi, and formation of placenta.Methods Immunohistochmical method was used to observe the distribution of LN and FN in normal chorion and decidual tissue during early pregnancy.Result LN and FN were positive stained in normal human chorion. LN was detected in the basement mebrane of placental villi and blood vessels, and decidual tissue, and FN was detected in the matrices of villi, basement membrane of blood vessels and decidual tissue.Conclusion LN and FN are important biofactors for adhesion and invasion of trophoblasts. They play an important role in the process of development of chorion villi and formation of placenta.

关 键 词：人胚 层粘连蛋白 纤维粘连蛋白 绒毛膜 蜕膜 

分 类 号：R321.4[医药卫生—人体解剖和组织胚胎学]