酯苷胶囊对小鼠移植瘤的抑制作用  

Inhibitive Effect of Zhigan Capsules on the Transplantation Tumor of Mice

作　　者：毕琳琳[1] 王四旺[1] 缪珊[1] 谢艳华[1] 

机构地区：[1]第四军医大学药学院天然药物学教研室,陕西西安710032

出　　处：《现代生物医学进展》2011年第23期4444-4446,4459,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金(2010JQ4019)

摘　　要：目的:探讨酯苷胶囊对小鼠移植性肿瘤的抑制作用。方法:采用小鼠移植性肿瘤模型,以5-FU为阳性对照组,观测2、4、8mg.kg-1酯苷胶囊对小鼠H22、S180肉瘤和HCA肝癌模型动物的抗肿瘤作用。结果:酯苷胶囊对H22、S180和HCA移植瘤的抑制率分别为36.8%～65.3%,19.0%～41.4%,46.8%～52.3%。结论:酯苷胶囊具有较强的抗肿瘤作用,显著延长荷瘤小鼠的生命。Objective： To discuss the inhibitive effect of Zhigan capsules on the transplantation tumor of mice. Methods： Use the model of transplantation tumor mice and take the 5-FU as the positive control group. Observe the respective anti-tumor effect of Zhigan capsules of 2, 4, 8 mg.kgt on tumor model of H22, S180 and HCA. Results： The inhibition rate of Zhigan capsules on transplantation tumor of H22, S180 and HCA were 36.8 %-65.3 %, 19.0 %-41.4 % and 46.8 %-52.3 %, respectively. Conclusions： Zhigan capsules had great anti-tumor effect, for it could greatly prolong the surviving time of mice bearing tumor.

关 键 词：酯苷胶囊 H22 S180 HCA 抗肿瘤作用 

分 类 号：Q95-3[生物学—动物学] R735.7[医药卫生—肿瘤]