HER-2原癌基因在乳腺癌中的异常表达  

Abnormal Expression of HER-2 Proto-Oncogene in the Patients with Breast Cancer.

作　　者：金晓明[1] 王小芹[1] 陆俐丽[2] 邓国仁[3] 

机构地区：[1]福建省医学科学研究所,350001 [2]福建省肿瘤医院 [3]北京市肿瘤研究所

出　　处：《福建医药杂志》1999年第6期3-5,共3页Fujian Medical Journal

摘　　要：采用分子杂交技术检测２例人原发性乳腺癌ＨＥＲ－２原癌基因ＤＮＡ及ＲＮＡ水平的改变。结果该基因在肿瘤组织未见扩增与重排，但其中１例在ＲＮＡ水平却异常表达，推测这种现象可能与该基因转录调控的失调有关。提示ＨＥＲ－２原癌基因的激活亦可能依赖其转录途径完成。The changes of DNA and RNA level of HER-2 proto-oncogene in 2 cases of human primary breast cancer were examined using molecular hybridization technique.The results showed that amplification and rearrangement of the gene had not been found in tumor tissues,however,in 1 case RNA expressed abnormally.We presumed that the phenomenon may be associated with imbalance of transcriptional regulation from the gene,which suggested that the HER-2 proto-oncogene activation may also be achieved by its transcriptional pathway.

关 键 词：乳腺癌 HER-2基因 基因异常表达 

分 类 号：R737.902[医药卫生—肿瘤]