MC、Vimentin及CEA在浆膜腔积液中恶性间皮瘤与转移癌的表达及其意义  

Expression and significance of MC,Vimentin and CEA in malignant mesothelioma and metastatic carcinoma in serous effusion

作　　者：李俊君[1] 撖俊[1] 朱江宁[1] 翟建英[1] 夏玉荣[1] 李忠[1] 

机构地区：[1]宁夏石嘴山市第二人民医院,宁夏石嘴山753200

出　　处：《宁夏医学杂志》2011年第11期1034-1036,1028,共3页Ningxia Medical Journal

摘　　要：目的探讨浆膜腔积液中恶性间皮瘤与转移癌的诊断及鉴别诊断。方法选择6例浆膜腔恶性间皮瘤、36例浆膜腔转移癌,采取涂片法与细胞蜡块切片免疫细胞化学相结合的方法进行对比观察。结果浆膜腔恶性间皮瘤与浆膜腔转移癌在形态上存在差异,浆膜腔恶性间皮瘤高表达MC(100%)、Vimentin(100%),与浆膜腔转移癌相比较,两者差异有统计学意义(P<0.05)。浆膜腔转移癌高表达CEA(83.3%),与浆膜腔恶性间皮瘤相比较,两者差异有统计学意义(P<0.05)。两者同时高表达EMA、P53,比较差异无统计学意义。结论涂片法与细胞蜡块切片免疫细胞化学相结合的方法可有效提高浆膜腔积液恶性肿瘤的诊断及鉴别诊断率。Objective To study the diagnosis and the differential diagnosis between malignant mesothelioma and metastatic carcinoma in serous effusion.Methods 6 cases with malignant mesothelioma and 36 cases with metastatic adenocarcinoma with serous effusions in the serous cavity were collected,and HE stained smears and immunohistochemistry with cell blocks for pathogical were observed.Results There were significantly different morphological characteristics between malignant mesothelioma and metastatic carcinoma in serous effusion（P0.05）.Compared with the metastatic carcinoma in serous effusion,the expression of MC and Vimentin was 100% in the malignant mesothelioma（P0.05）.Compared with the malignant mesothelioma in serous effusion,the expression of CEA was 83.3% in the metastatic carcinoma in serous effusion（P0.05）.The expression of EMA and P53 was not different in the malignant mesothelioma and the metastatic carcinoma in serous effusion and there was not significant difference（P0.05）.Conclusion The combination of HE staining and immunohistochemistry with cell blocks is helpful for the diagnosis and the differential diagnosis between malignant mesothelioma and metastatic carcinoma in serous effusion.

关 键 词：浆膜腔积液 恶性间皮瘤 转移癌 免疫组化 

分 类 号：R730.2[医药卫生—肿瘤]