梅州市客家妇女感染人HPV类型分析  

Analysis the Epidemiologic Distribution of Human Papilloma Virus(HPV) Genotypes in Meizhou Area

作　　者：李利平[1] 苏鲁贤[1] 吴成勇[1] 杨满[1] 丘媚妮[1] 

机构地区：[1]广东省梅州市人民医院,广东梅州514003

出　　处：《河北医学》2011年第12期1626-1630,共5页Hebei Medicine

摘　　要：目的:了解梅州客家地区不同年龄段女性生殖道人乳头瘤病毒(HPV)感染状况及其分布规律,为梅州客家地区HPV分子流行病学研究提供依据。方法:以2008年2月至2010年8月来我院就诊的12919例可疑患者为对象,采集其阴道宫颈分泌物标本。用凯普医用核酸分子杂交系统进行21种HPV(cp8304、6、11、16、18、31、33、35、39、42、43、45、44、51、52、53、56、58、59、66、68)基因型的分型检测,分析常见感染亚型和分布规律。结果:HPV阳性总检出率为21.8%(2822/12919),高危型主要为HPVl6,其余依次为HPV58、52、31、33感染。低危型主要为HPV11、6感染;各年龄组总HPV阳性率居前3位的是40-44岁,30-34岁,35-39岁。结论:HPV基因型HPV16(5.60%)、HPV58(2.74%)、HPV52(2.70%)、HPV31(2.14%)和HPV33(1.28%)是梅州客家地区HPV感染的主要型别,不同年龄段HPV阳性率有显著性差异(P<O.05),对HPV阳性者进行定期跟踪是防治宫颈癌的重点。Objective： To study the distribution pattern of HPV genotypes in different age groups of women in Meizhou area.Method： Cervical tissue specimens from 12919 women were examined with DNA extract PCR and nucleic acid hybridization technique（cape medical system）to determine the HPV genotypes associated with the infected specimens（including HPV cp8304,6,11,16,18,31,33,35,39,42,43,44,45,51,52,53,56,58,59,66,68）.Result：HPV was detected with a positive rate of 21.8%（2822/12919）.Among the higll risk genotypes,HPV 16 was the most prevalent（5.60%）,followed by HPV58,52,31,33 in order.The low risk genotypes consisted of chiefly HPV 11,HPV6.HPV positive rate in different age groups was 40-44 years,30-34 years,35-39 years.Conclusion：The most prevalent HPV genotypes in women of Meizhou area are HPV16（5.60%）,HPV58（2.74%）,HPV52（2.70%）,HPV31（2.14%） and HPV33（1.28%）,with significance difference among the HPV positive rates in different age groups.HPV16 is the most hish risk genotype in specimens.Regular follow-up is most desirable in infected cases.

关 键 词：人乳头瘤病毒 基因型 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]