膀胱移行细胞癌PCNA表达与预后的关系  

Expression ofPCNAin transitionalcellcarcinom a ofurinary bladder and its clinicalsignificance

作　　者：于冬梅[1] 梁智勇[1] 柳凤轩[1] 闫晓初[1] 刘丽梅[1] 

机构地区：[1]第三军医大学附属西南医院病理科,重庆400038

出　　处：《第三军医大学学报》1999年第12期902-903,共2页Journal of Third Military Medical University

摘　　要：目的：检测膀胱移行细胞癌中增殖细胞核抗原（ＰＣＮＡ）的表达，探讨与膀胱移行细胞癌预后的关系。方法：应用免疫组织化学技术，检测５５例膀胱移行细胞癌ＰＣＮＡ的表达。结果：５５例膀胱移行细胞癌中，ＰＣＮＡ标记指数随病理分级增高和肿瘤体积增大而增高，Ⅰ、Ⅱ、Ⅲ级间均有非常显著差异（Ｐ＜ ０．０１）。ＰＣＮＡ标记指数高表达者死亡率明显高于低表达者（Ｐ＜ ０．０１）。结论：ＰＣＮＡ是判断膀胱移行细胞癌恶性程度和预后的一个重要标志。Objective: To study the relationship ofthe expression ofPCNA in bladdertransitionalcell carcinoma (TCC) with theprognosisofthem alignancy.Methods: Theexpression ofPCNAwasdeterm ined in 55 casesoftransitionalcellcarcinom aoftheurinary bladderw ith im m unohistochemistry. Results: In the 55 cases ofTCCof the urinary bladder, the expression ofPCNA was increased with the grading and the enlargem entofthe sizeofthem alignancy. Theexpression ratewassignificantly differentbetween grades Ⅰ and Ⅱand between grades Ⅱand Ⅲ(P< 0.01). The m ortality w as higher in the patients w ith higher expression rate ofPCNA than in those with lower expression rate. Conclusion: The expression rate of PCNAis a usefulindex to predicttheoutcom eofthe patients with bladderTCC.

关 键 词：膀胱移行细胞癌 膀胱肿瘤 PCNA 预后 

分 类 号：R737.140.2[医药卫生—肿瘤]