β-环糊精与阿霉素表面包络作用的电化学研究  

Electrochemical Studies on Surface Inclusion of β-Cyclodextrin with Adriamycin

作　　者：石健[1] 张其平[1] 王南平[1] 

机构地区：[1]南通大学化学化工学院,江苏南通226007

出　　处：《电化学》2011年第4期433-437,共5页Journal of Electrochemistry

基　　金：江苏省自然科学基金重点项目(BK2010034)资助

摘　　要：研究了阿霉素(ADM)在β-环糊精(β-CD)修饰金电极上(β-CD/Au)的电化学行为.结果表明,ADM在β-CD/Au电极上发生表面包络反应.25℃,pH=7.0时,该电极表面包络常数为9.54×104 L.mol-1,并随温度呈规律性变化,最适宜反应温度为30℃.该电极ADM包络呈准可逆的电化学反应,速率常数为0.0995 s-1.在20～40μmol.L-1浓度范围β-CD/Au电极ADM的还原峰电流与浓度呈线性关系,线性方程Ip=2.024+0.0057C,相关系数0.9911,检出限6.5μmol.L-1.The β-cyclodextrin（β-CD） modified gold electrode（β-CD/Au） was fabricated to study the electrochemical behavior of adriamycin（ADM）.The results indicated that the complexing reaction of ADM with β-CD took place at the β-CD/Au surface.At 25 ℃,the complexing constant（k） was 9.54×104 L·mol-1 in pH=7.0.The k values changed regularly with temperature,and the most suitable temperature of the surface inclusion reaction was 30 ℃.The complexing reaction of ADM with β-CD at the β-CD/Au surface could undergo the quasi-reversible electrochemical reaction with the rate constant being 0.0995 s-1.The cathodic peak current（Ip） of ADM was proportional to the concentration of ADM in the 20~40 μmol·L^-1.The linear regression equation for the quantitative determination of ADM concentration（C） by β-CD/Au was Ip=2.024＋0.0057C with a correlation coefficient of 0.9911.The detection limit was 6.5 μmol·L-1.

关 键 词：阿霉素 Β-环糊精 修饰电极 包络 

分 类 号：R965[医药卫生—药理学]