核素因子分析显像对原发性肝细胞癌诊断价值的研究  

Diagnosis of early stage hepatocellular carcinoma with radionuclide factor analysis imaging

作　　者：徐文贵[1] 牛刚[1] 张英男[1] 马庆杰[1] 王成[1] 李中军[1] 高凤桐[1] 杨昆[2] 穆雅丽 

机构地区：[1]白求恩医科大学第三临床学院核医学科,长春130031 [2]白求恩医科大学预防医学院毒理教研室 [3]长春职工医科大学

出　　处：《中国老年学杂志》1999年第6期332-333,共2页Chinese Journal of Gerontology

基　　金：吉林省科委资助

摘　　要：目的　利用因子分析显像对原发性肝细胞癌（ＨＣＣ）进行定性、定位诊断研究。方法　对正常１６ 例，ＨＣＣ １３ 例，肝海绵状血管瘤２１ 例经肘静脉“弹丸”方式注入９９ｍ Ｔｃ 洗脱液３７０ ＭＢｑ（体积＜ １ ｍ ｌ）后，立刻以１ 帧／５ ｓ的速度连续采集３６ 帧，通过感兴趣区法扣除肝外影像，经图像放大，取２８～３２ 个动态像素处理，提取肝实质相因子图像，肝动脉灌注相因子图像。结果　１３ 例ＨＣＣ动脉灌注因子图像中１１ 例于占位区呈浓聚像，而正常人和肝血管瘤者未见异常浓聚，诊断效能评价，因子分析法对ＨＣＣ的诊断灵敏度８４．６％ ，特异性１００％ 。结论　因子分析法对ＨＣＣ的诊断具有较高的灵敏度和特异性，值得推广和应用。The purpose was to qualify and localize the lesions of hepatic cellular carcinoma(HCC) using radionuclide factor analysis imaging.Methods 16 normal volunteers, 13 patients with HCC and 21 with hepatic spongy hemangioma were injected 370 MBq 99m Tc04 elute. 36 frames were acqusited immediately at the rate of 5 frames per second with matrix 64×64, enlargement 1.5. The part out of liver was subtracted with ROI technique. After enlarging, 28～32 dixels were processed to extract hepatic artery phase, hepatocellar phase and their factor curves respectively. Results The results showed that the space occupying lesions in 11 out of 13 patients with HCC were visualized in the hepatic artery phase while that in the normals and the patients with hepatic spongy hemangioma were negative.Conclusions The sensitivity of HCC diagnosis was 84.6% and the speciality 100%. The factor analysis is sensitive and special for HCC diagnosis and has great value in clinical applications.

关 键 词：因子分析 放射性核素显像 原发性 肝细胞癌 诊断 

分 类 号：R735.704[医药卫生—肿瘤]