急性脑出血患者外周血sFas和sFasL的变化及意义  

Changes of levels of sFas and sFasL in acute cerebral hemorrhage and its significance

作　　者：王兆平[1] 王文静[1] 时鹏[1] 王前友 潘健[1] 马俊芳[1] 吴蕾[1] 

机构地区：[1]安徽医科大学附属省立医院,合肥230001

出　　处：《山东医药》2011年第41期4-6,共3页Shandong Medical Journal

基　　金：安徽省卫生厅科研课题计划项目(2010C032)

摘　　要：目的探讨急性脑出血(ACH)患者可溶性Fas(sFas)和可溶性Fas配体(sFasL)的变化与出血量、部位、形态及ACH病情变化的关系。方法 ACH患者60例为病例组,同期无脑血管疾病体检者30例为对照组。采用ELISA法测定血清sFas和sFasL,并按出血灶大小、部位、形状进行分组,比较各组之间sFas和sFasL差异。结果 ACH组6 h血清sFas低于对照组(P<0.01),24 h、2 d、7 d血清sFas高于对照组(P<0.01),ACH组6 h、24 h、2 d、7 d血清sFasL高于对照组(P<0.01),血清sFas和sFasL峰值与出血灶的大小、部位、形态有关(P均<0.01)。结论血浆sFas、sFasL的峰值高可能提示ACH患者的出血灶较大、形态不规则和预后较差。Objective To investigate the relationship between the changes of the serum levels of soluble Fas（sFas）,soluble Fas-ligand（sFasL） and the size,location and form of hemorrhage and its condition changes in acute cerebral hemorrhage（ACH） patients.Methods Sixty cases of ACH patients were recruited as the experimental group and 30 cases of the volunteers without cerebrovascular disease as the control group.The serum levels of sFas and sFasL were measured by enzyme-linked immunosorbent assay（ELISA） method in both groups and all ACH patients were grouped according to the size,location and form of hemorrhage.The differences in the levels of sFas and sFasL were compared among each groups.Results The levels of serum sFas at 6-hour after onset in ACH group were lower than those in the control group（P0.01）,and were higher than those in the control group at 24-hour,day 2 and 7 after onset（P0.01）.The levels of serum sFasL in ACH group were higher than those in the control group at 6-hour,24-hour,day 2 and 7 after onset（P0.01）.There were significantly correlation between the serum peak levels of sFas and sFasL and the size,location and form of hemorrhage in the experimental group.Conclusion The increased peak levels of sFas and sFasL serum may suggest there has larger hemorrhage,irregular hemorrhage and the poorly outcome in ACH patients.

关 键 词：脑出血 SFAS SFASL 细胞凋亡 

分 类 号：R743.34[医药卫生—神经病学与精神病学]