DCRRT治疗重症急性胰腺炎并急性肺损伤的临床观察  

Clinical observation of daytime continuous renal replacement therapy on severe acute pancreatitis with acute lung injury

作　　者：龚园其[1] 詹亚琨[1] 程斌[1] 胡东霞[1] 李国平[1] 

机构地区：[1]南昌大学第二附属医院,南昌330006

出　　处：《山东医药》2011年第45期7-9,共3页Shandong Medical Journal

基　　金：江西省卫生厅科技计划项目(20091111)

摘　　要：目的探讨日间连续性肾替代疗法(DCRRT)治疗重症急性胰腺炎(SAP)并急性肺损伤(ALI)的临床疗效。方法将40例SAP并ALI患者随机分为DCRRT组、对照组各20例,检测两组治疗前后血浆TNF-α、IL-6、IL-8,比较其生命体征、氧合指数、急性生理与慢性健康评估评分(APACHEⅡ评分)、机械通气时间、ICU住院时间及病死率。结果与对照组比较,DCRRT组TNF-α、IL-6、IL-8下降,生命体征好转,氧合指数提高,APACHEⅡ评分下降,机械通气及ICU住院时间缩短,病死率降低(P<0.01或<0.05)。结论 DCRRT能促进SAP并ALI患者的肺功能恢复,减少机械通气时间,缩短ICU住院时间,降低病死率。Objective To research the clinical therapeutic effect of daytime continuous renal replacement therapy（DCRRT） on severe acute pancreatitis（SAP） with acute lung injury（ALI）.Methods Forty patients suffered SAP with ALI were randomly divided into DCRRT group（20 patients） and control group（20 patients）.The plasma levels of TNF-α,IL-6,IL-8 were detected.The vital sign,oxygenation index,the acute physiology and chronic health evaluation Ⅱ（APACHE Ⅱ） score,the time of mechanical ventilation,the length of stay of ICU and death rate between two groups were compared.Results Compared with control group,the plasma levels of TNF-α,IL-6,IL-8 were decreased,the clinical representation was improved,oxygenation indexes were raised.The APACHEⅡ score,time of mechanical ventilation,length of stay of ICU and the death rate were decreased（P0.01 or 0.05）.Conclusions DCRRT can improve the function of lung in SAP,decrease the time of mechanical ventilation,the length of stay of ICU and the death rate.

关 键 词：胰腺炎 急性 肺损伤 急性 肾替代治疗 连续性 日间 

分 类 号：R576[医药卫生—消化系统]