原发性甲状腺恶性淋巴瘤10例临床分析  

Clinical analysis of 10 cases of primary thyroid lymphoma

作　　者：周韬[1] 莫军扬[1] 朱其一[1] 黄平[1] 庄亚强[1] 

机构地区：[1]广西医科大学第五附属医院乳腺甲状腺外科,广西柳州545006

出　　处：《重庆医学》2011年第34期3460-3461,3464,共3页Chongqing medicine

摘　　要：目的总结原发性甲状腺恶性淋巴瘤(PTL)的诊断和治疗经验。方法 10例PLT患者采用甲状腺全切除术、CHOP方案(环磷酰胺,阿霉素,长春新碱)化疗及术后放疗,回顾性分析其临床特点及疗效。结果术前9例患者被误诊为甲状腺癌,1例误诊为结节性甲状腺肿。10例患者均行甲状腺全切除术,4例颈部淋巴结有转移的患者行甲状腺全切除及颈部淋巴结清扫术。术后行化疗9例,放疗1例。所有患者术后病理诊断为甲状腺弥漫性大B细胞淋巴瘤(DLBCL)。6例伴有桥本甲状腺炎(HT)。术后随访至2010年10月31日,存活9例,死亡1例。结论 PTL诊断困难,PTL的发病与HT有关,手术治疗及术后综合治疗可提高患者的治愈率及生存率。Objective To summarize the diagnostic and therapeutic experience of primary thyroid lymphoma（PTL）.Methods 10 patients with PLT were treated with total thyroidectomy,CHOP scheme（cyclophosphamide,doxorubicin,vincristine） chemotherapy and postoperative radiotherapy.The clinical features and therapeutic effect of these patients were retrospectively analyzed.Results 9 patients were preoperatively misdiagnosed as thyroid carcinoma,1 as nodular goiter.All 10 patients were subjected to total thyroidectomy,among which 4 cases of cervical lymph node metastasis carrying out total thyroidectomy and cervical lymph node dissection.Postoperative chemotherapy was administrated in 9 cases and radiotherapy in 1 case.All patients were pathologically diagnosed with thyroid diffuse large B-cell lymphoma（DLBCL）.6 patients were accompanied by Hashimoto′s thyroiditis（HT）.Postoperative follow-up until October 31,2010 showed 9 survivals and 1 death.Conclusion PTL is difficult to diagnose of which pathogenesis is related to HT.Surgical and postoperative comprehensive therapy can improve the cure rate and survival rate of patients.

关 键 词：甲状腺肿瘤 淋巴瘤 甲状腺切除术 甲状腺炎 诊断 

分 类 号：R736.1[医药卫生—肿瘤]