DDP联合CTX节律化疗治疗晚期神经母细胞瘤疗效观察  

The application value of the metronomic chemotherapy of the DDP, CTX in the treatment of children with neuroblastoma

作　　者：廖君左[1] 王城[1] 蒋琳[2] 周柯均[1] 赵丹[1] 

机构地区：[1]川北医学院附属医院小儿外科,四川南充637000 [2]川北医学院附属医院肿瘤科,四川南充637000

出　　处：《中国现代医药杂志》2011年第11期14-16,共3页Modern Medicine Journal of China

摘　　要：目的探讨DDP、CTX小剂量持续化疗在儿童神经母细胞瘤治疗中的应用价值。方法将25例患儿随机分为A、B两组;A组给予常规治疗方案(CTX700mg/m2,d3和DDP80mg/m2分4天使用,3周为一个疗程),B组给予节律化疗方案(CTX90mg/m2和DDP10mg/m2)。观察两组病例治疗的有效率及手术切除率。结果 A组13例,化疗总疗程71例次,有效率10/13(76.9%);B组12例,化疗总疗程数90例次,有效率11/12(91.7%)。两组患儿化疗后手术切除率分别为61.5%、75.0%,两组比较差异无统计学意义(P>0.05);不良反应发生率分别为42.3%、3.3%,两组比较差异有统计学意义(P<0.05)。结论两种化疗方案在本次实验中治疗的有效率无明显差异,节律化疗方案能明显减少化疗的不良反应。Objective To evaluate the application value of the low-dose continuous DDP, CTX metronomic chemotherapy in the treatment of children with neuroblastoma. Methods The patients were randomly divided into A, B groups. A group received conventional treatment（CTX 700mg/m2, d3 and DDP 80mg/m2, four days using the 3-week course of treatment）, B group was given metronomic chemotherapy（CTX 90mg/m2 and DDP 10mg/m2）. To observe the efficient rate and resection rate of the two groups. Results The total course of chemotherapy for A group with 13 patients was 71, the efficient was 10/13 （76.9%）. The total course of chemotherapy for B group with 12 patients was 90, and the efficient was 11/12（91.7%）. The resection rates of the two groups after chemotherapy were 61.5% and 75.0%, respectively. The difference was not statistically significant（P0.05）.The adverse reaction rates were 42.3% and 3.3%, respectively. The difference was statistically significant（P0.05）. Conclusion There were no significant differences of effective rates between the two groups, but the metronomic chemotherapy can significantly reduce the adverse effects of chemotherapy.

关 键 词：节律化疗 神经母细胞瘤 

分 类 号：R739.4[医药卫生—肿瘤]