生存素基因蛋白和阻抑素在胃癌中的表达及意义  

The expression and effect of survivin and prohibitin gene in gastric carcinoma

作　　者：王波[1] 邵晴[2] 秦继宝[1] 

机构地区：[1]江苏省连云港市东方医院检验科,222042 [2]江苏省连云港市第一人民医院消化科,222001

出　　处：《检验医学与临床》2011年第23期2862-2863,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨生存素基因蛋白(Survivin)和阻抑素(Prohibitin)在胃癌组织中的表达及二者相关的临床意义。方法用免疫组织化学SP法检测胃癌组织及癌旁组织、正常胃黏膜中Prohibitin与Survivin的表达,比较其阳性表达率及Prohibitin与Survivin的关系。结果 Survivin在胃癌中阳性表达率为75.5%(40/53),明显高于癌旁组织和正常胃黏膜(P<0.05);Prohibitin在胃癌中的表达率为84.9%(45/53),明显高于癌旁组织和正常胃黏膜(P<0.01);胃癌组织中Survivin与Prohibitin的表达呈正相关(P<0.01)。结论 Survivin和Prohibitin在胃癌中过度表达,提示二者在胃癌的发生、发展中起重要作用;Survivin和Prohibitin通过抗凋亡机制协同参与胃癌的发生。Objective To observe the expression and the relationship of sruvivin and prohibitin gene in gastric carcinoma.Methods The expressions of survivin and prohibitin were detected by SP immunohistochemistry in gastric carcinoma,paracancerous tissue and normal gastric mucosa tissues.Results The positive survivin expression rate was 75.5%（40/53） in tumor tissues.and that of prohibitin was 84.9%（45/53）.Both were significantly higher than those in the paracancerous tissue and normal gastric mucosa tissues.The expressions of survivin and prohibitin in gastric carcinoma were closely correlated with each other（P0.01）.Conclusion The overexpression of survivin and prohibitin indicated that they both play important roles in the development of gastric carcinoma.They infect the carcinogenesis of gastric carcinoma through anti-apoptosis mechanism.

关 键 词：胃癌 生存素基因蛋白 阻抑素 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]