肝细胞癌患者血清IL-6、IL-2系统的变化及相互关系  

Significance of Changes of IL-6, IL-2 System in Patientswith Hepatocellular Carcinoma

作　　者：赵彩彦[1] 王彦锁 周俊英[1] 张素环[1] 冯忠军[1] 

机构地区：[1]河北医科大学附属第三医院,石家庄市050051 [2]石家庄市卫生防疫站

出　　处：《中国肿瘤临床》1999年第11期826-828,共3页Chinese Journal of Clinical Oncology

基　　金：河北省教委科研基金资助 !( 编号 952404)

摘　　要：目的:研究肝细胞癌患者IL- 6、IL- 2 、sIL- 2R 的变化和意义。方法:分别采用ABS- ELISA 法、双抗体夹心ELISA 法对40 例肝癌患者进行了IL- 6 、IL- 2 、sIL- 2R 的测定,并与26 例肝炎肝硬化和66 例健康献血员进行了对照。结果:肝细胞癌( HCC) 患者血清IL- 6 、sIL- 2R 水平明显升高,而IL- 2 水平明显低于正常对照(NC)组( P< 0.01) ,HCC 组的IL- 6 水平高出正常10 倍以上, 较肝硬化组明显升高( P< 0.01) , 临床晚期肝癌患者的IL- 6 水平显著高于临床早期。IL- 6 与sIL- 2R 显著正相关,而与IL- 2 无相关关系。结论:肝细胞癌患者存在免疫功能紊乱和低下、淋巴因子网络失衡, 这与其病理生理机制有关, 也为临床上HCC 应用IL- 2 治疗提供了理论依据。IL- 6 的显著增高有助于HCC 的早期诊断。Objective: To study the significance of changes of IL-6, IL-2, sIL-2R in patients with hepatocellular carcinoma (HCC).Methods: IL-6, IL-2, sIL-2R were determined by avidin-biotin-system ELISA,double-sandwich ELISA respectively in 40 patients with HCC and 26 patients with liver cirrhosis (LC) and 66 healthy persons as control. Results: The levels of IL-6, sIL-2R increased remarkably, but the levels of IL-2 were markedly lower in HCC patients than those in the control group (P< 0.01). The IL-6 levels in HCC group were 10 times higher than those in normal control and also much higher than those of LC. IL -6 level was higher in late stage than in earlier stage.There was a positive correlation between IL-6 and sIL-2R, but none between IL-2 and IL-6, sIL-2R in HCC . Conclusion: The immunologic disorder, and imbalance of lymphokine network may be correlated with the pathophysiologic changes in HCC patients. The results provide the rationale for use of Il-2 in the treatment of HCC. A remarkably higher level of IL -6 is helpful for early diagnosis of HCC.

关 键 词：肝细胞癌 IL-6 IL-2 SIL-2R 

分 类 号：R735.703[医药卫生—肿瘤]