丙戊酸钠治疗癫痫300例临床分析  

Clinical Analysis of 300 Epilepsy Cases Treated by Sodium Valproate

作　　者：李格[1] 杨小华[1] 

机构地区：[1]天门市第一人民医院神经内科,湖北天门431700

出　　处：《神经损伤与功能重建》2011年第6期420-422,共3页Neural Injury and Functional Reconstruction

摘　　要：目的:观察丙戊酸钠治疗临床各种类型癫痫的疗效和安全性。方法:各种类型癫痫患者300例,给予丙戊酸钠单药治疗,儿童剂量20～30mg/(kg.d),成人剂量600～1200mg/d,从开始接受治疗起,连续观察12个月。比较服药前后患者癫痫发作次数,并记录分析药物不良反应。结果:丙戊酸钠治疗各型癫痫的有效率达88.33%(265/300);其中发作控制103例(34.33%),显效117例(39%),有效45例(15%),无效33例(11%),恶化2例(0.67%);不良反应较轻。结论:丙戊酸钠是一种安全、对大部分癫痫有效的抗癫痫药物。Objective： To investigate the efficacy and safeness of sodium valproate （VPA） in treating epilepsy. Methods： Three hundred of patients with different kinds of epilepsy were re- cruited and treated with VPA. The dosage was 20-30 mg/（kg d） for children and 600-1200 mg/d for adults. All patients were followed up for 12 months. The frequencies of seizures before and after the treatment were compared and the side-effects of VPA were analyzed. Re- sults： The total effective rate of VPA treatment was 88. 33O//oo （265/300）, in which 103 cases （34.33%） were completely seizure-free, 117 cases （39%） showed satisfactory seizure-control, and 45 cases （15%） showed partially seizure-control. But 33 cases （11%） did not show any im- provement and 2 cases （0. 67%） showed aggravated seizure attacks. The side-effects of VPA were mild. Conclusion： VPA is an effective and safe drug in treating most kinds of epilepsy.

关 键 词：丙戊酸钠 癫痫 疗效 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]