铜绿假单胞菌注射液腔内注入治疗23例恶性心包积液的临床观察  

Treatment of 23 cases of malignant hydropericardium with intracavitary administration of pseudomonas aeruginosa injection

作　　者：朱亚芳[1] 魏金芝[1] 顾洪兵[1] 

机构地区：[1]南通市肿瘤医院内科,江苏南通226361

出　　处：《现代肿瘤医学》2011年第12期2458-2459,共2页Journal of Modern Oncology

摘　　要：目的:观察铜绿假单胞菌注射液(PA-MSHA)腔内注入治疗恶性心包积液的疗效及安全性。方法:对23例恶性心包积液患者,先心包腔内置入中心静脉导管行持续引流,待积液基本排尽后注入PA-MSHA 2-3ml和地塞米松5mg。夹闭引流管5-7天后复查B超,如效果不佳则再次引流后重复注射上述药物,反之则拔管。结果:共治疗23例,完全缓解14例(60.9%),部分缓解7例(30.4%),总有效率91.3%。心包腔内注药后有5例发热,2例胸痛。结论:PA-MSHA腔内注入治疗恶性心包积液疗效满意,不良反应不大。Objective：To evaluate the efficacy of pseudomonas aeruginosa injection（PA-MSHA） in treatment of malignant hydrropericardium.Methods：Twenty-three patients with malignant hydropericardium were enrolled.After drairage of effusion by inserting central venous catheter into pericardial cavity,all patients were injected with 2-3ml of PA-MSHA and 5mg of dexamethasome.Ultrasound was performed to show pericardial exudates 5-7 days after injection of PA-MSHA.Patients who had a poor response after 5-7 days will have a second injection of PA-MSHA.Results： The effective rate was 91.3% for malignant hydropericardium.The adverse effects included fever（5 cases） and chest pain（2 cases）.Conclusion： Intracavitary administration of PA-MSHA is an effective,safe method for the treatment of malignant hydropercardium.

关 键 词：恶性心包积液 铜绿假单胞菌 心包穿刺 

分 类 号：R730.6[医药卫生—肿瘤]