原发性肝癌肝动脉化疗栓塞术(TACE)预后多因素分析  

Prognostic factors affecting TACE treatment in patients with primary hepatic carcinoma

作　　者：商春雨[1,2] 苏洪英[1] 刘静[1] 韩向军[1] 徐克[1] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001 [2]四平市中心人民医院介入科,辽宁四平136000

出　　处：《现代肿瘤医学》2011年第12期2466-2469,共4页Journal of Modern Oncology

基　　金：十一五国家科技支撑项目计划一级协作(编号:2007BAI05B06)

摘　　要：目的:分析影响TACE预后的主要因素。方法:收集120例资料完整的原发性肝癌患者,对各变量进行单因素分析,再用多因素Cox逐步回归分析影响预后的因素。结果:单因素分析与预后有关的有治疗次数、肿瘤类型、门脉癌栓、碘油沉积类型、肿瘤缩小率、肝癌分期(BCLC);多因素分析与预后相关的有显著意义的因素变量为治疗次数、肿瘤类型、门脉癌栓、肿瘤缩小率。结论:肝功能允许的情况下,多次治疗可以延长患者的生存时间;小肝癌患者中位生存时间明显高于结节型、块型及巨块型;门脉癌栓为预后危险性因素,门脉主干癌栓患者中位生存时间明显降低;PR患者中位生存时间明显延长。Objective：To investigate the impact of TACE treatment prognostic factors.Methods：Total of 120 cases of PHC patients with complete data were selected,single-factor analysis and then multivariate Cox regression analysis were performed on the prognostic factors.Results：Univariate analysis： frequency of treatment,tumor type,portal vein tumor thrombus,the type of iodized oil deposition,tumor shrinkage rate of liver cancer staging（BCLC） were prognostic variables.Prognostic factors in multivariate analysis were frequency of treatment,tumor type,portal vein tumor thrombus,tumor regression rate.Conclusion：Retreatment can improve the survival rate.The median survival time of patients with small hepatocellular carcinoma was significantly higher than nodular type,block type and bulky;Portal cancerous thrombus was risk factor affecting prognosis.Patients with portal vein tumor thrombus in the median survival time was significantly reduced;Patients of PR whose survival rate was better than the other types.

关 键 词：原发性肝癌 化疗栓塞 预后 回归分析 

分 类 号：R735.7[医药卫生—肿瘤]