支气管哮喘患儿治疗前后血清CGRP、MMP-9和TIMP-1检测的临床意义  

Clinical Significance of Determination the Changes of Serum CGRP,MMP-9 and TIMP-1 Levels Both Before and After Treatment in Pediatric Patients with Bronchial Asthma

作　　者：陈桂金[1] 

机构地区：[1]江苏省常州市第七人民医院检验科,213011

出　　处：《放射免疫学杂志》2011年第6期621-622,共2页Journal of Radioimmanology

摘　　要：目的:探讨了支气管哮喘患儿治疗前后血清CGRP、MMP-9和TIMP-1水平的变化及临床意义。方法:应用放射免疫分析和酶联法对32例支气管哮喘患儿进行了治疗前后血清CGRP、MMP-9和TIMP-1检测,并与35名正常健康儿作比较。结果:在治疗前支气管哮喘患儿血清CGRP水平非常显著地低于正常儿组(P<0.01),而MMP-9、TIMP-1水平又非常显著地高于正常儿组(P<0.01),经治疗3个月后与正常儿组比较无显著性差异(P>0.05)。结论:血清CGRP水平降低和MMP-9、TIMP-1水平升高是支气管哮喘患儿发病的病理因素之一,有重要的临床价值。Objective To explore the changes of serum CGRP,MMP-9 and TIMP-1 levels after treatment in pediatric patients with bronchial asthma.Methods Serum CGRP（with RIA）,MMP-9,TIMP-1（with ELISA） levels were measured in 32 patients with bronchial asthma both before and after treatment as well as in 35 controls.Results Before treatment,the serum CGRP levels was significantly lower in patients than those in controls（P0.01）,While the serum MMP-9,TIMP-1 levels was significantly higher than those in controls（P0.01）,After 3 months treatment,the levels were not evidently different from those in controls（P0.05）.Conclusion Abnormal lower CGRP and high MMP-9,TIMP-1 levels might play an important role in the pathogenesis and development of bronchial asthma in children.

关 键 词：支气管哮喘 降钙素基因相关肽 基质金属蛋白酶-9 基质金属蛋白酶组织抑制剂-1 

分 类 号：R575.2[医药卫生—消化系统]