曲唑酮治疗阿尔茨海默病伴发精神行为症状的临床研究  

The clinical research on the treatment of trazodone in the behavioral and psychological symptom of demential.

作　　者：衣磊[1] 张桂敏[1] 孙波[1] 

机构地区：[1]山东省青岛市精神卫生中心老年一科,266034

出　　处：《四川精神卫生》2011年第4期218-220,共3页Sichuan Mental Health

摘　　要：目的比较曲唑酮与奥氮平治疗阿尔茨海默病伴发精神行为症状的疗效及不良反应。方法将71例伴发精神行为症状的阿尔茨海默病患者随机分为两组,分别以曲唑酮(36例)和奥氮平(35例)治疗,疗程均为8周;分别于治疗前后采用痴呆行为量表(BRSD)及治疗时出现的症状量表(TESS)评定两组疗效及不良反应,并进行比较。结果曲唑酮和奥氮平治疗阿尔茨海默病伴发精神行为症状的显效率分别为52.8%和54.3%,两组间差异无统计学意义(P>0.05);曲唑酮组和奥氮平组不良反应发生率分别为13.9%和37.1%,曲唑酮组不良反应的发生率明显低于奥氮平组,差异有统计学意义(P<0.05)。结论曲唑酮和奥氮平对阿尔茨海默病伴发精神行为症状均有明显疗效,但曲唑酮不良反应发生率更低、安全性更高。Objective To compare the curative effect and adverse effect of the treatment in BPSD between trazodone and olanzapine.Methods 71 patients suffered from BPSD were devided into two groups randomly which were treated with trazodone and olanzapine respectively.The course of treatment was 8 weeks.All patients were assessed with BRSD and TESS to compare the results.Results The excellence rate of trazodone and olanzapine was 52.8% and 54.3%（P0.05）respectively.All patients in two groups were assessed with BRSD before and after the treatment that shew statistical significances in the difference.The rates of deverse effect were 13.9% and 37.1% respectively（P0.05）.Conclusion There was certain curative therapy and higher security in the treatment of trazodone on BPSD.

关 键 词：曲唑酮 阿尔茨海默病 精神行为症状 

分 类 号：R749.16[医药卫生—神经病学与精神病学]