新型纳米复合材料对犬下颌牙槽骨缺损的修复效果  

Effect of new nanometer composite materials on dogs mandibular alveolar bone defect

作　　者：孔丽[1] 唐旭炎[1] 李全利[1] 

机构地区：[1]安徽医科大学附属口腔医学院,合肥230032

出　　处：《安徽医科大学学报》2011年第12期1245-1248,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:30772440);安徽省科技攻关计划项目(编号:08010302196)

摘　　要：目的评价新型纳米复合材料对犬下颌牙槽骨缺损的修复效果。方法选用6只成年杂种犬,在双侧下颌前磨牙和第一磨牙颊侧手术制备3个5 mm×5 mm×5 mm大小的牙槽骨缺损,骨缺损区分别放入新型纳米复合材料与自体富血小板血浆混合物(A组)、新型纳米复合材料(B组),并以不放入任何材料为空白对照(C组)。根据大体观察、影像学和组织学观察对实验结果进行评价。结果术后2周,A、B、C 3组新骨形成不明显,三者无明显差异;术后4、12周,A、B两组新骨形成优于C组。结论新型纳米复合材料可以有效地促进犬下颌牙槽骨的再生,材料中加入自体富血小板血浆效果更加明显。Objective To evaluate the effect of new nano-eomposite materials on dogs mandibular alveolar bone defect. Methods 3 bone defects of 5 mm × 5 mm× 5 mm size were surgical prepared in 6 adult mongrel dogs in the mandibular premolar and first molar buccal. Bone defects were placed in new nano-composite materials and mixtures of autologous platelet-rich plasma （ A group）, the new nano-eomposite material （ B group）, and had no any material control （C group）. Based on gross observation, radiographic and histological evaluation of experimental results. Results Three groups of new bone formation was not obvious for 2 weeks, no significant difference was found between the three groups; A, B groups of new bone formation was better than that in C group for 4, 12 weeks, in particular, new bone formation in 12 weeks. Conclusion New nano-composite materials can effectively promote the regeneration of canine mandibular alveolar bone, material with adding autologous platelet-rich plasma is more evident.

关 键 词：复合材料 牙周组织再生 牙槽骨缺损 

分 类 号：R781.4[医药卫生—口腔医学]