秀丽线虫转基因品系在环境暴露评价与毒理学研究中的应用  

Application of Transgenic Strains of Caenorhabditis elegans in Studies on Environmental Exposure Evaluation and Environmental Toxicology

作　　者：王大勇[1] 

机构地区：[1]东南大学医学院生物化学与分子生物学系,南京210009

出　　处：《生态毒理学报》2011年第6期561-570,共10页Asian Journal of Ecotoxicology

基　　金：国家重点基础研究发展计划(No.2011CB933404)

摘　　要：目前,模式动物秀丽线虫已被广泛应用于环境暴露评价和环境毒理学研究中。在系统介绍了各种秀丽线虫转基因品系在环境暴露与毒性评价以及环境毒理研究中的应用进展基础上,分析了秀丽线虫转基因品系在环境暴露与毒性评价研究中的灵敏性与直观性的特点。最后,讨论了秀丽线虫转基因品系在环境暴露与毒性评价以及环境毒理研究中尚存在的问题和可能的解决策略。So far, Caenorhabditis elegc^s as a model animal has been widely used in the studies on environmental expo- sure evaluation and environmental toxicology. In this review, the recent progresses in the application of transgenic strains of Caenorhabditis elegans for studies on environmental exposure evaluation and environmental toxicology were systematically introduced. The characteristics of being sensitive and directly visualized, which are the main characteris- tics of transgenic strains of Caenorhabditis elegans in toxicity evaluation of environmental exposure, were analyzed. On this basis, the questions needed to be solved and the suggestions for solutions were discussed so as to make better ap- plications of transgenic strains of Caenorhabditis elegcrns in environmental exposure evaluation and environmental toxi- cology.

关 键 词：转基因品系 环境暴露 环境毒理 秀丽线虫 

分 类 号：X171.5[环境科学与工程—环境科学]