广东汉族人群Toll样受体4基因多态性与颅内外动脉粥样硬化及脑梗死的关系  

Relation of Toll-like receptor 4 gene polymorphisms to artherosclerosis and cerebral infarction in Guangdong Han population

作　　者：梁燕玲[1] 许治强[1] 匡永锋[1] 刘宇明[1] 

机构地区：[1]广州医学院第三附属医院神经内科,510150

出　　处：《临床神经病学杂志》2011年第6期401-403,共3页Journal of Clinical Neurology

基　　金：广东省科技计划项目(2009B030801352);广州医学院博士启动课题(2006GD080)

摘　　要：目的探讨广东汉族人群Toll样受体4(TLR4)基因A299G和C399T多态性与颅内外动脉粥样硬化及脑梗死的关系。方法住院及门诊的广东汉族患者200例,根据临床表现、头颅影像学、全脑血管造影、颈动脉彩超或经颅多普勒超声(TCD)检查结果及伴有的脑卒中危险因素分为5组,(1)脑梗死并颅内外动脉粥样硬化性狭窄组(40例),(2)脑梗死无颅内外动脉粥样硬化性狭窄组(40例),(3)颅内外动脉粥样硬化性狭窄而无脑梗死组(40例),(4)有≥3种脑血管病危险因素而无颅内外动脉粥样硬化性狭窄及脑梗死组(40例),(5)正常对照组(40例)。采用DNA测序法检测各组TLR4基因中A299G和C399T的基因型和等位基因频率。结果各组均未见TLR4基因中A299G和C399T多态性的存在。结论广东汉族人群TLR4基因A299G和C399T多态性可能与颅内外动脉粥样硬化及脑梗死无相关性。Objective To explore the relation of Toll-like receptor 4 （TLR4） gene polymorphisms to artheroselerosis and cerebral infarction in Guangdong Han population. Methods Two hundred in-patients and outpatients were divided into 5 groups according to the clinical manifestations, the test results of skull imaging, digital subtraction angiography, carotid artery color dopplar ultrasound or transcranial doppler ultrasound and with the risk factories of stroke. （ 1 ） Group with cerebral infarction and features of artherosclerotic stenosis in intracranial or extracranial arteries （40 cases）. （2） Group with cerebral infarction, but without features of artherosclerotie stenosis in intracranial or extracranial arteries （40 cases）. （3） Group with features of artherosclerotie stenosis in intracranial or extracranial arteries, but without cerebral infarction （40 cases）. （4） Group with ≥ 3 risk factories for stroke, but without cerebral infarction or features of artherosclerotic stenosis in intracranial or extracranial arteries （40 cases ）. （5） Normal control group （40 cases）. The polymorphisms of the TLR4 gene A299G and C399T were detected using gene sequencing method. Results The polymorphisms of the TLR4 gene A299G and C399T were not found out in any of the 5 groups. Conclusion There is no association between TLR4 gene A299G and C399T polymorphisms and artherosclerosis or cerebral infarction in Guangdong Han population.

关 键 词：TOLL样受体4 动脉粥样硬化 脑梗死 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]