海洛因成瘾者扣带前回结构与功能连接的MRI研究  

MRI study of the structure and functional connectivity of anterior cingulate cortex in heroin addicts

作　　者：伊涛[1] 傅先明[1] 钱若兵[1] 季学兵[2] 魏祥品[1] 林彬[1] 胡文富[1] 牛朝诗[1] 汪业汉[1] 

机构地区：[1]安徽医科大学附属省立医院神经外科,合肥230001 [2]安徽医科大学附属省立医院磁共振室,合肥230001

出　　处：《中国微侵袭神经外科杂志》2011年第12期541-544,共4页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家自然科学基金(编号:30670683;30973084);安徽省自然科学基金(编号:070413264X;11040606M167);安徽省卫生厅医学科研课题(编号:09B137)

摘　　要：目的利用基于体素的形态学分析(voxel-based morphometry,VBM)和静息态fMRI探讨扣带前回结构和功能连接的改变,分析扣带前回在海洛因成瘾中的作用。方法 15例海洛因成瘾者和15例正常人分别作为成瘾组和正常对照组,均接受3D结构像和静息态fMRI检查,使用VBM比较2组受试者大脑的结构差异;以扣带前回为感兴趣区,对2组进行静息态fMRI数据分析,比较扣带前回与相关脑区之间功能连接的差异。结果 VBM分析显示2组在左右扣带前回、左右海马旁回、左右尾状核等处灰质密度有显著性差异。以扣带前回为感兴趣回,成瘾组左右海马旁回、左右扣带前回、左右扣带后回等脑区的功能连接较正常对照组减弱。结论长期海洛因成瘾者扣带前回结构和功能连接出现异常,提示扣带前回在药物成瘾发生、维持和戒断后复吸中发挥重要作用。Objective To explore changes of the structure and functional connectivity of anterior cingulate cortex （ACC） and analyze the role of ACC in heroin addiction by voxel-based morphometry （VBM） and resting-state functional MRI （fMRI）. Methods Fifteen heroin addicts and 15 normal people were set as addiction group and normal control group respectively, who underwent 3-dimensional structural imaging and resting-state fMRI. The VBM was used to compare the structural differences between the two groups. The ACC was selected as the regions of interest （ROI） to analyze the resting-state fMRI data of two groups in order to investigate the differences in functional connectivity between the ACC and related brain regions. Results VBM results showed that there were significant differences in gray matter density of right and left ACCs, right and left parahippocampal gyri, right and left caudate nuclei between two groups. When the ACC was selected as ROI, functional connectivity in some brain regions including the right and left ACCs, right and left posterior cingulate cortexes （PCCs） and the right and left parahippocampal gyri were weaker in addiction group than in normal control group. Conclusions The unusual changes of structure and functional connectivity appear in long-term heroin addicts, suggesting that ACC may play an important role in generation and maintain of addiction, and also in relapse after drug withdraw.

关 键 词：海洛因依赖 扣带回 前 形态学分析 基于体素 磁共振成像 功能 功能连接 

分 类 号：R749.64[医药卫生—神经病学与精神病学]