新型巯基聚合物-壳聚糖谷胱甘肽的合成研究  

Preparation of Chitosan–glutathione

作　　者：张建中[1] 陈小燕[1] 王银萍[1] 胡征[1] 

机构地区：[1]扬子江药业集团,江苏泰州225321

出　　处：《中国医药指南》2011年第34期262-264,共3页Guide of China Medicine

摘　　要：目的巯基聚合物利用二硫键的形成,以共价键黏附于黏膜表面,可以延长药物在黏膜上的滞留时间,有利于药物分子的吸收。以壳聚糖为原料,对其巯基进行修饰,制得一种新型巯基聚合物。方法以高密度壳聚糖为原料,用谷胱甘肽对其进行修饰,合成壳聚糖谷胱甘肽。结果通过考察反应液的pH值,壳聚糖、GSH、EDAC及NHS加入量,最佳工艺制得的壳聚糖-谷胱甘肽巯基含量为(277.4±12.1)μmol/g,达到预期目标。objective The use of mucoadhesive thiolated polymers as the carriers can improve the adsorption of drugs by prolonging the residence time on the mucosa on the basis of the formation of disulphide bonds between thiol groups on polymer and cysteine-rich domains of mucus glycoproteins.Fabricate the sulfhydryl group of chitosan and prepare the desired new type of polymer.Methods Fabricate high density chitosan with glutathione to obtain the desired final molecular-chitosan-glutathione.Results Observe and find the best ratio of chitosan,GSH,EDAC,and NHS,and the purity of sulfhydryl group in the final preparation is（277.4±12.1）μmol/g.

关 键 词：壳聚糖 谷胱甘肽 巯基聚合物 修饰 

分 类 号：R914.1[医药卫生—药物化学]