舍曲林联合喹硫平治疗强迫症对照研究  

A control study of sertraline combined with quetiapine in the treatment of obsessive-compulsive disorder

作　　者：姜静[1] 李林[1] 

机构地区：[1]宁夏精神卫生中心,宁夏·灵武750400

出　　处：《临床心身疾病杂志》2011年第6期508-509,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 探讨舍曲林联合喹硫平治疗强迫症的临床疗效和安全性.方法 将64例强迫症患者随机分为两组,每组32例,两组均口服舍曲林治疗,研究组联合喹硫平治疗.观察8周.于治疗前及治疗8周末采用Yale-Brown强迫量表、汉密顿焦虑量表、汉密顿抑郁量表评定临床疗效,于治疗2周、4周、6周、8周末采用副反应量表评定不良反应.结果 治疗后两组Yale-Brown强迫量表、汉密顿焦虑量表、汉密顿抑郁量表评分均较治疗前有显著下降（P＜0.01）,但研究组同期各量表评分均较对照组下降更显著（P＜0.05）;治疗8周末研究组显效率78.1%、有效率93.8%,对照组分别为53.1%、78.1%,研究组显效率显著高于对照组（χ2=4.433,P＜0.05）.两组不良反应均轻微,治疗各时段副反应量表评分差异均无显著性（P＞0.05）.结论 舍曲林联合喹硫平治疗强迫症可增加疗效,显著优于单用舍曲林治疗,且安全性高,值得临床推广应用.Objective To explore the clinical efficacy and safety of sertraline cornbined with quetiapine in the treatment of obsessive-compulsive disorder （OCD）. Methods Sixty-four OCD patients were randomly divided into two groups of 32 ones each, both groups took orally sertraline and re- search group was plus quetiapine for 8 weeks. Clinical efficacies were assessed with the Yale-Brown Obsessive-Compulsive Disorder Scale （Y-BOCS）, Hamilton Depression Scale （HAMD） and Hamilton Anxiety Scale （HAMA） aat the end of the 8th week and adverse reactions with the Ttreatment Emergent Symptom Scale （TESS） at the end of the 2nd , 4th, 6th and 8th week. Results After treatment, the Y-BOCS, HAMA and HAMD scores lowered more significantly compared with pretreatment （P〈0.01）, so did those in the research than in the control group in the corresponding period （P〈0.05） ; at the end of the 8th week, obvious effective and effective rates were 78.1% and 93.8% in the research and 53.1% and 78.1% in the control group, obviuos effective rate was significantly higher in the former （）C2= 4. 433, P〈0.05）. Adverse reactions of both groups were mild, each period score of the TESS had no significant difference （P〉0.05）. Conclusion Sertraline combined with quetiapine can increase curative effect in the treatment of obsessive-compulsive disorder, has an advantage over single-use sertraline and higher safety and is worthy to be popularized clinically.

关 键 词：强迫症 喹硫平 舍曲林 YALE-BROWN强迫量表 副反应量表 

分 类 号：R749[医药卫生—神经病学与精神病学] R749.055[医药卫生—临床医学]