甲硫腺苷磷酸化酶基因多态性与脑梗死的相关性  

Association between polymorphisms of methylthioadenosine phosphorylase gene and cerebral infarction in Chinese Han

作　　者：刘波[1] 冯慧琼[1] 包秀荣[1] 

机构地区：[1]包头医学院第一附属医院神经内科,内蒙古014010

出　　处：《脑与神经疾病杂志》2011年第6期435-438,共4页Journal of Brain and Nervous Diseases

基　　金：包头市医药卫生科技计划项目(2009S1001-45);内蒙古卫生厅医疗卫生科研计划项目(2010066)

摘　　要：目的探讨甲硫腺苷磷酸化酶(MTAP)基因多态性及其与脑梗死发病的关系。方法以rs10118757位点为遗传标记,采用聚合酶链式反应和限制性片段长度多态性(PCR-RFLP)方法检测196例脑梗死患者和130例对照者的基因型。用Logistic回归分析基因多态性与脑梗死的关系。结果脑梗死组G等位基因频率较对照组明显增高(χ2=5.691,P=0.017),脑梗死组GA+GG基因型频率较对照组明显增高(χ2=85.267,P=0.000)。Logistic回归分析显示MTAP基因rs10118757位点GA+GG基因型是脑梗死发病的独立危险因素。结论 MTAP基因rs10118757位点多态性与脑梗死的发病可能有关,GG+AG基因型为脑梗死患者发病的独立危险因素。Objective To investigate the genetic association between the methyhhioadennsine phosphorylase gene pnlymorphism and cerebral infarelion. Methods 196 patients with cerebral infarction were recruited into this study,and 130 heahhv people were included as cnnlrols. SNP rs10118757 were used as genetic markers. PCR-based restriction fragment length polymorphism analysis was applied to genotype rsl0118757. Results Tbe frequencies of allele G was significantl.~ higher in patients than controls （ X2 = 5. 691, P = 0. 017 ）, the frequeneies of GA ＋ GG genotype were significantly higher in patients than controls （ X2 = 85. 267, P = 0. 000）. Conclusions The present stndy suggests that the methylthioadenosine phosphorylase gene polymorphism of rsl0118757 is likely to contribute to the etiology of eerebral infarction in Chinese HaM. GA ＋ GG genotype may be the pathogenetic heredity risk factor of cerebral infarction.

关 键 词：甲硫腺苷磷酸化酶 单核苷酸多态性 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]