55例癫痫病人应用镇痉剂的疗效与血浓度关系  

Relationship between the Curative Effect and Serum Concentration of Antispasmodic in 55 Patients with Epilepsy

作　　者：郭明光[1] 钱可久[1] 朱丽华[1] 

机构地区：[1]上海第二医科大学附属仁济医院神经内科,上海200001

出　　处：《现代诊断与治疗》1999年第B12期10-12,共3页Modern Diagnosis and Treatment

摘　　要：目的　观察抗痫药物的疗效与血浓度的关系。方法　用抑制免疫速率散射比浊法测定了 5 5例癫痫患者的苯妥因钠、鲁米那、卡马西平的药物血浓度。结果　单用药物的血浆浓度有效率达 73 .3 % ,合并用药有效率达 6 3 .9%。结论　该方法快速、敏感、简便 ,对癫痫的治疗提供了可靠的实验室数据 ,本研究提示在癫痫治疗过程中进行治疗药物监测是非常必要的。Objective To observe the relationship between the curative effect and serum concentration of antipasmodic.Method By using immunosuppressant rate nephelometry,we determined the serum concentration of dilantin,luminal and tegretol in 55 patients with epilepsy.Results By using single drug,the effective rate of the serum concentration amounted to 73.3%,and by using combined drugs,to 63.9%.Conclusions This method is fast,sensitive,simple and gives reliable laboratory data.This study indicates that in the course of treatment of epilepsy it is very necessary to monitor treatment drugs.

关 键 词：癫痫 镇痉剂 血药浓度 疗效 

分 类 号：R742.105[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]