酵母葡聚糖对金葡菌灭活苗免疫新西兰兔效果的影响  

Effect of Yeast Glucan Enhanced Vaccine on the Immune Function in New Zealand Rabbit

作　　者：王成龙[1,2] 王英珍[2] 李引乾[1] 孙英峰[2] 张健[2] 池晶晶[2] 王东[2] 李秀丽[2] 任卫科[2] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]天津市畜牧兽医研究所,天津300112

出　　处：《西北农业学报》2011年第9期1-4,共4页Acta Agriculturae Boreali-occidentalis Sinica

基　　金：天津市科技支撑计划重点项目(09ZCGYNC00100)

摘　　要：为了研究酵母葡聚糖对金黄色葡萄球菌油乳剂灭活苗免疫新西兰兔效果的影响,将其添加到金黄色葡萄球菌油乳剂灭活苗中,配制成低(5 g/L)、中(10 g/L)、高(15 g/L)3个剂量的酵母葡聚糖金黄色葡萄球菌油乳剂灭活苗,同时用不添加酵母葡聚糖的金黄色葡萄球菌油乳剂灭活苗和生理盐水作为对照,分别给每只新西兰兔皮下注射1 mL,在注射后第7、14、21、31、41和51天,分别采血检测新西兰兔淋巴细胞转化率和抗体水平。结果表明,中剂量(10 g/L)的酵母葡聚糖金黄色葡萄球菌油乳剂灭活苗能明显提高新西兰兔的淋巴细胞转换率和血清抗体水平。说明灭活苗中添加适量的酵母葡聚糖能提高疫苗的免疫效力,增强新西兰兔的免疫功能。The present study investigated the effects of Yeast Glucan enhanced vaccine on immune function of New Zealand Rabbit.Yeast Glucan was administrated by injection with inactive vaccine which was prepared in bovine-derived Staphylococcus aureus and oil emulsion in three doses（5,10,15 g/L）.The control group was set without Yeast Glucan.Blood samples were collected at 7,14,21,31,41,and 51 days after incubation from New Zealand rabbits,and lymphocyte transformation rate and the antibody levels were evaluated corresponding.The results indicated that enhanced vaccine with 10 mg per rabbit could significantly enhance the lymphocyte transformation rate and the antibody levels.So inactivated vaccine added proper amount of Yeast Glucan can improve the vaccine effectiveness and enhance the immune function of New Zealand rabbit.

关 键 词：酵母葡聚糖 新西兰兔 淋巴细胞转化率 抗体水平 

分 类 号：S858.291[农业科学—临床兽医学]