COX-2基因多态性与食管癌易感性关系的Meta分析  

COX-2 Polymorphism and Susceptibility to Esophageal Cancer: A Meta-analysis

作　　者：唐巍峰[1] 孙斌[1] 顾海勇[1] 丁国文[1] 陈锁成[1] 

机构地区：[1]江苏大学附属人民医院胸外科,江苏镇江212000

出　　处：《中国循证医学杂志》2011年第12期1391-1394,共4页Chinese Journal of Evidence-based Medicine

摘　　要：目的探讨COX-2基因多态性与食管癌易感性的关系。方法计算机检索PubMed和EMbase数据库,检索时间截至2011年1月1日,获取COX-2基因多态性与食管癌易感性关系的病例-对照研究。以食管癌组与对照组人群基因型分布的OR值及其95%CI为效应指标,在纯合子模型、显性模型和隐性模型中采用固定或随机效应模型进行Meta分析,并进行发表偏倚评估。统计分析采用Stata 11.0软件。结果共纳入5个病例-对照研究。Meta分析结果显示:在COX-2-765G>C多态性位点,显性模型中,与野生基因型GG相比,CC+GC合并的OR值(95%CI)为1.806(1.050,3.106),其余为阴性结果。在COX-2-1195G>A多态性位点中,纯合子模型、显性模型及隐性模型均为阳性结果。结论 COX-2基因多态性与食管癌易感性可能相关。Objective To investigate the relationship between cyclooxygenase-2（COX-2） gene polymorphism and genetic susceptibility to esophageal cancer.Methods e PubMed and EMbase databases were searched from the date of their establishment to January 1st,2011 to collect the case-control studies on COX-2 polymorphism and susceptibility to esophageal cancer.For the population genotype distributions of both esophagus cancer group and control group,their odds ratios（ORs） and 95% con dence intervals（CIs） were taken as the e ect indexes,either the xed or random e ect model was applied to conducted Meta-analysis in homozygote comparison,dominant and recessive genetic models,and the publication bias was assessed then.All statistical analyses were conducted with Stata11.0 so ware.Results A total of ve case-control studies were included.e results of meta-analyses showed for the COX-2-765GC polymorphism,the CC＋GC genotype was associated with the risk of esophageal cancer in a dominant genetic model（CC＋GC vs.GG： OR=1.806,95% CI 1.050 to 3.106）;for the COX-2-1195GA polymorphism,the AA genotype was associated with the risk of esophageal cancer in homozygote comparison and recessive genetic models,the AA＋GA genotype was associated with the risk of esophageal cancer in a dominant genetic model.Conclusion It is suggested that COX-2 polymorphism may be associated with genetic susceptibility to esophageal cancer.

关 键 词：COX-2 食管癌 基因多态性 病例-对照研究 META分析 

分 类 号：R735.1[医药卫生—肿瘤]