端粒与肿瘤细胞耐药关系的研究进展  

Progress on the relationship between telomere and chemoresistance in cancer cells

作　　者：蒋春艳[1] 孟祥宁[1] 白静[1] 金焰 孙文靖[1] 傅松滨[1] 

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081 [2]黑龙江省普通高等学校医学遗传学重点实验室,哈尔滨150081

出　　处：《国际遗传学杂志》2011年第6期326-332,共7页International Journal of Genetics

基　　金：973计划前期研究专项（2010CB534901）;教育部新世纪优秀人才支持计划（NCET-08-06T1,NCET-10-149）

摘　　要：端粒是人类染色体末端结构，在维持基因组稳定性中发挥重要作用。有丝分裂导致的端粒长度的进行性缩短是细胞衰老的标志，肿瘤细胞则克服了这种现象，保留了无限增殖的能力，故端粒成为临床治疗的靶点。肿瘤细胞对化疗药物的耐受现象是临床治疗的难题。如何克服肿瘤的耐药性一直是肿瘤治疗研究的重点。该文从端粒的基本组成结构人手，对端粒与肿瘤细胞获得性耐药的关系以及端粒如何介导肿瘤细胞耐药性的产生进行综述，旨在为克服肿瘤耐药性提供新的治疗思路。Chemoresistance in cancer cell is a big challenge in tumor therapy, and how to overcome this phenomenon is still the emphasis of the cancer study. Telomere is a structure at the end of chromosome, playing an important role in maintaining genome stability. The progressive shortening of telomere length by mitosis is the hallmark of cell senescence. However, tumor ceils which overcome this phenomenon, retain the ability of proliferation indefinitely. Therefore, telomere becomes a target of clinical treatment. This review summarizes the variation and the potential functions of telomeres in chemoresistance cancer cells, in order to explore new therapeutic methods to overcome chemoresistance in cancer.

关 键 词：端粒 端粒酶 耐药性 肿瘤 

分 类 号：R730[医药卫生—肿瘤]