伴中央中颞区棘波的儿童良性癫痫患者治疗前后异常SPECT灌注灶的变化  

Changes of SPECT abnormal perfusinon loci in paleints with benign epilepsy of chidren with centromidtemporal spikes

作　　者：宋文珺[1] 党小利[1] 吴银瓶[1] 王为民[1] 

机构地区：[1]兰州大学第二医院癫痫中心,甘肃省癫痫防治中心,甘肃兰州730030

出　　处：《癫痫与神经电生理学杂志》2011年第6期341-345,共5页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：观察伴中央中颞区棘波的儿童良性癫痫（BECT）长期控制中发作间期单光子发射断层扫描（SPECT）异常灌注灶恢复情况和V—EEG的变化。方法：观察25例BECT患儿经抗癫痫药治疗前后发作间期SPECT显像与长程EEG及影像学的变化。结果：控制发作时间平均30个月，用药前后SPECT、两次比较：用药后SPECT正常增加10例（67％，P〈0．05）；低灌注减少1例（33％）和高灌注减少9例（53％），单灶减少9例（64％），多灶减少1例（17％）。EEG比较：用药后正常增加7例（28％，7／25；P〈0．05），CT和（或）MRI检查均无异常。结论：抗癫痫药物可改善BECT的异常灌注灶和减少痫样放电，部分异常灌注灶经治疗可修复。Objective：To explore dynamic changes of interictcal SPECT abnormal perfusion fQci and V-EEG in patients with benign epilepsy of children centromidtemporal spikes（BECT） in long-term control of antiepileptic drugs（AEDs）. Methods： Twenty-five patients with BECT were selected with AEDs treatment of long term control. Before and after interictcal SPECT ,long-term V-EEG and imaging examination were finished in the patients. Results：The average time of the whole control was 30 months. With twice comparison：the normal SPECT increased in 10 case（67.0%,P〈0.05） ; respectively, hypoperfusion loci was reduced in 1 case（33%） and hyperperfusion loci decreased in 9 case（53%） , single foci and polyfoci decreased respectively in 9 case and 1case（64.0% and 17.0%）. With twice comparison of the nomal V-EEG was increased in 7 cases （28.0 %, 7/25, P〈0.05）. The CT/MRI was normal . Conclusions： The AEDs can affecte abnormal perfusion foci of SPE.CT and epileptic discharges of EEG in the pateints with BECT and part of abnormal perfusion foci could be repaired.

关 键 词：伴中央中颞区棘波的儿童良性癫痫(BECT) 单光子发射断层扫描(SPECT) 异常灌注灶 修复 脑电图(EEG) 痢样放电 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]