S100A4蛋白在卵巢浆液性腺癌中的表达及其临床意义  

Expression of S100A4 protein in ovarian serous adenocarcinoma

作　　者：朱安娜[1,2,3] 李俊东[1,2] 冯艳玲[1,2] 徐漫漫[1,2] 肖娟[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室 [2]中山大学肿瘤防治中心妇科,广东广州510060 [3]汕头大学医学院附属肿瘤医院妇科,广东汕头515000

出　　处：《中国病理生理杂志》2011年第12期2253-2257,共5页Chinese Journal of Pathophysiology

基　　金：广东省科技计划(No.2009B030801021)

摘　　要：目的:分析S100A4蛋白在卵巢浆液性腺癌中的表达及其与临床病理因素和预后的关系,探讨其在卵巢浆液性腺癌侵袭转移过程中的作用及判断卵巢浆液性腺癌患者预后的价值。方法:用免疫组化方法检测S100A4蛋白在卵巢浆液性腺癌、卵巢浆液性腺瘤及卵巢交界性浆液性腺瘤组织中的表达,分析S100A4蛋白的表达与卵巢浆液性腺癌各临床病理因素及生存预后的关系。结果:S100A4蛋白表达定位在肿瘤细胞的细胞质和细胞核,在卵巢浆液性腺癌、卵巢交界性浆液性腺瘤和卵巢浆液性腺瘤组织中的高表达率分别为78%、30%和27%,S100A4蛋白在卵巢浆液性腺癌组织中的高表达率高于其它两个对照组,差异有统计学意义。S100A4蛋白表达与卵巢浆液性腺癌患者的病理分级、治疗后是否复发有关(均P<0.05)。单因素分析显示患者无疾病进展时间和总生存时间均与S100A4蛋白表达有关(P<0.05)。多因素Cox回归分析显示术后残留病灶大小和病理分级是影响卵巢浆液性腺癌预后的独立因素。结论:S100A4蛋白表达上调在卵巢浆液性腺癌的发生过程中可能起一定作用。病理分级高的卵巢浆液性腺癌细胞可能部分通过上调S100A4蛋白表达增强其侵袭转移能力。S100A4蛋白可能成为对卵巢浆液性腺癌患者复发风险预测和预后判断的指标之一。AIM： To observe the expression of S100A4 protein in ovarian serous carcinoma and to explore the relationship between the protein expression of S100A4 and the clinicopathological features/prognosis of the patients with ovarian serous adenocarcinoma.METHODS： The expression levels of S100A4 protein in ovarian serous adenocarcinoma,ovarian serous adenoma and ovarian borderline serous adenoma were detected by the method of immunohistochemistry.The relationship between the expression of S100A4 protein and the clinicopathological features/survival of the patients was statistically analyzed.RESULTS： The results of immunohistochemistry showed that the positive expression of S100A4 protein was located in karyon and cytoplasm.The high expression rates were 78% in ovarian serous adenocarcinoma,30% in ovarian borderline serous adenoma and 27% in ovarian serous adenoma.The high expression rate of S100A4 protein in ovarian serous adenocarcinoma group was higher than that in any of the 2 control groups,and the difference was statistically significant.The high expression of S100A4 protein in ovarian serous adenocarcinoma was significantly correlated to tumor differentiation and recurrence after treatment（P0.05）.Survival analysis was performed in 69 cases of ovarian serous adenocarcinoma and the result of single-factor analysis showed that the expression of S100A4 protein was the correlative factor of progression-free survival and overall survival（P0.05）.The result of Cox proportional hazards regression model analysis indicated that residual disease after surgery and tumor differentiation were the independent prognostic factors of ovarian serous adenocarcinoma.CONCLUSION： Up-regulation of S100A4 protein may play a role in the carcinogenesis and development of ovarian serous adenocarcinoma.Ovarian serous adenocarcinoma with high grade may enhance the abilities of invasiveness and metastasis partly by the way of up-regulation of S100A4 protein expression.S100A4 protein may be one of the biological markers for recurre

关 键 词：蛋白质S100A4 卵巢肿瘤 预后 

分 类 号：R737.31[医药卫生—肿瘤]