PU.1转录因子调控前体脂肪细胞生脂的分子机制研究进展  

Progress of PU.1-regulated Adipogenesis in Preadipocytes

作　　者：庞卫军[1,2] 卫宁[1] 熊燕[1] 王平[1] 童强 

机构地区：[1]西北农林科技大学动物肌肉发育与脂肪沉积实验室,杨凌712100 [2]贝勒医学院儿童营养研究中心,休斯敦77030

出　　处：《中国细胞生物学学报》2011年第12期1394-1400,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30600437);西北农林科技大学青年学术骨干支持计划(No.0114030);西北农林科技大学基本科研业务费专项资金(No.QN2009021)资助项目~~

摘　　要：PU.1转录因子是保守的DNA结合蛋白Ets家族成员,因其DNA结合区识别共有序列GAGGAA,故该区又称为Ets结合区或PU.1box。PU.1主要在造血系统如髓细胞和B淋巴细胞中表达,调节关键髓系基因的转录从而调控造血系统的分化。PU.1周身敲除后,由于胎儿肝脏中缺乏B淋巴细胞和髓系细胞,导致小鼠胚胎早期死亡,表明PU.1是调控生命过程的关键转录因子。目前,在脂肪细胞中PU.1对脂肪生成作用及机制的研究报道较少。PU.1与脂肪细胞脂肪生成,与miRNAs、antisense RNA以及C/EBPα/β-PPARγ通路的调控关系将是今后研究的重点。PU. 1 transcription factor is a member of conserved DNA-binding proteins which is called Ets family. As the common sequence GAGGAA is recognized in their DNA-binding region, it is named Ets binding region or PU. 1 box. PU. 1 mainly expresses in the hematopoietic system, such as myeloid cells and B lymphocytes, regulating the transcription of key myeloid genes to control the differentiation of the hematopoietic system. Global PU. 1 deficiency in mouse leads to early embryonic death due to lack of fetal liver B lymphocytes and myeloid cells, indicating that PU. 1 is a key transcription factor in control of life process. By now, effect ofPU. 1 on adipocyte adipogenesis and its mechanism have been rarely reported. The relationship between PU. 1 and regulation of miRNAs, antisense RNA and C/EBPa/fl-PPARγ pathway during adipocyte adipogenesis will be the focus of future research.

关 键 词：PU.1 ANTISENSE RNA MIRNAS 前体脂肪细胞 生脂 

分 类 号：Q25[生物学—细胞生物学]