ANTISENSE

作品数：326被引量：1003H指数：16
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相关机构：军事医学科学院浙江大学医学院附属第一医院北京大学湖南医科大学更多>>
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Efficient Modulation of Exon Skipping via Antisense Circular RNAs
《Research》2023年第3期485-490,共6页Shuaiwei Ren Mei Huang Raoxian Bai Lijiao Chen Jiao Yang Junyu Zhang Wenting Guo Weizhi Ji Yongchang Chen 
the National Natural Science Foundation of China(grant numbers 81930121 and 82125008);STI2030-Major projects(grant number 2021ZD0200900);the National Key Research and Development Program of China(grant numbers 2018YFA0801403 and 2018YFA0107902);the Natural Science Foundation of Yunnan Province(grant numbers 202001BC070001 and 202102AA100053)。
Splice-switching antisense oligonucleotides(ASOs)and engineered U7 small nuclear ribonucleoprotein(U7 Sm OPT)are the most commonly used methods for exon skipping.However,challenges remain,such as limited organ deliver...
关键词：ENDOGENOUS DYSTROPHY DUCHENNE 
Identification of novel antisense long non-coding RNA APMAP-AS that modulates porcine adipogenic differentiation and inflammatory responses
《Journal of Integrative Agriculture》2023年第8期2483-2499,共17页ZHANG Lin-zhen HE Li WANG Ning AN Jia-hua ZHANG Gen CHAI Jin WU Yu-jie DAI Chang-jiu LI Xiao-han LIAN Ting LI Ming-zhou JIN Long 
supported by grants from the National Key R&D Program of China(2021YFA0805903,2020YFA0509500 and 2021YFD1300800);the Sichuan Science and Technology Program,China(2021ZDZX0008,2021YFYZ0009,2021YFYZ0030 and 2022JDJQ0054).
Long non-coding RNAs(lncRNAs)are emerging as powerful regulators of adipocyte differentiation,fat metabolism and gene expression.However,the functional roles and mechanisms of lncRNAs in these processes remain unclear...
关键词：lncRNA ADIPOGENESIS lipid metabolism INFLAMMATION RNA-RNA duplex 
Investigation on small molecule-aptamer dissociation equilibria based on antisense displacement probe
《Food Science and Human Wellness》2023年第4期1257-1264,共8页Lei Wang Lili Yao Qihui Ma Yu Mao Hao Qu Lei Zheng 
supported by the National Key R&D Program of China(2017YFC1600603);the Funds for Huangshan Professorship of Hefei University of Technology(407-037019).
Food safety is a major issue to public health and have attracted global attention.Fast,sensitive,and reliable detection methods for food hazardous substances is highly desirable.Aptamers which can bind to the target m...
关键词：APTAMER Small molecule Dissociation equilibria Antisense displacement probe Le Chatelier’s principle 
Spotlight:Antisense regulation of miRNA action during phosphate starvation被引量：1
《Molecular Plant》2023年第8期1249-1251,共3页Soledad Traubenik Martin Crespi 
supported by the LUMIROOT project funded by the Marie Sktodowska-Curie Actions and the MICROLUP project(ANR MICROLUP 19-CE13-0029-02NA);funded by the Agence Nationale de la Recherche ANR,France.IPS2 benefits from the support of Saclay Plant Sciences-SPS(ANR-17-EUR-0007).
Phosphorus(P)is a vital nutrient for plant growth,acquired primarily in the form of inorganic phosphate(Pi).Pi deficiency limits plant growth and development and significantly constrains crop productivity worldwide.To...
关键词：ARABIDOPSIS action INORGANIC 
A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells被引量：2
《Current Medical Science》2022年第4期681-691,共11页He CHENG Er-shao ZHANG Xiao SHI Ping-ping CAO Bei-jing PAN Xin-xin SI Yue LIU Nan YANG Ying CHU Xu-chun WANG Xiao HAN Zhi-hong ZHANG Yu-jie SUN 
supported by the National Natural Science Foundation of China(No.81802670 and No.82072580).
Objective:The ataxia telangiectasia mutated(ATM)gene is a master regulator in cellular DNA damage response.The dysregulation of ATM expression is frequent in breast cancer,and is known to be involved in the carcinogen...
关键词：antisense transcript ataxia telangiectasia mutated ataxia telangiectasia mutatedantisense breast cancer KAT5 
lncRNA DDX11-AS1靶向miR-299-3p调控宫颈癌细胞增殖、迁移和侵袭被引量：1
《实用预防医学》2022年第6期754-758,共5页车艳红 梁菁苹 赵莹 刘娅 杨慧丽 
目的探讨长链非编码RNA(long non-coding RNA,lncRNA)DDX11反义RNA1(DDX11 antisense 1,DDX11-AS1)靶向miR-299-3p对宫颈癌细胞增殖、迁移侵袭的影响。方法实时荧光定量PCR(RT-qPCR)检测宫颈癌组织、癌旁组织中DDX11-AS1和miR-299-3p表...
关键词：DDX11 antisense 1 DDX11-AS1 miR-299-3p 宫颈癌 细胞增殖 迁移侵袭 
The group of Professor Xinjing Tang has made progress in the study of cyclic antisense oligonucleotides as microRNA inhibitors
《Journal of Chinese Pharmaceutical Sciences》2021年第10期855-856,共2页无 
2021年10月21日,北京大学药学院天然药物及仿生药物国家重点实验室汤新景研究团队在学术期刊《Journalof Medicinal Chemistry》发表了最新研究成果"Circular Antisense Oligonucleotides for Specific RNase-H-Mediated micro RNA Inhi...
关键词：北京大学药学院 反义寡聚核苷酸 学术期刊 ANTISENSE 最新研究成果 
LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients被引量：7
《Cancer Biology & Medicine》2021年第3期675-692,共18页Haihua Tian Jinchang Pan Shuai Fang Chengwei Zhou Hui Tian Jinxian He Weiyu Shen Xiaodan Meng Xiaofeng Jin Zhaohui Gong 
supported in part by research grants from the Non-profit Technology Research Program of Zhejiang(Grant No.LGF18H160006);the Natural Science Foundation of Zhejiang(Grant No.LQ18H200001);the Non-profit Technology Research Program of Ningbo(Grant No.2019C50040);the Natural Science Foundation of Ningbo(Grant No.2018A610204);the Major Project for Science and Technology Innovation 2025 of Ningbo(Grant No.2019B10037);the K.C.Wong Magna Fund at Ningbo University。
Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PC...
关键词：Antisense long noncoding RNA DPP10-AS1 HYPOMETHYLATION malignant process lung cancer 
What do we know about the role of lncRNAs in multiple sclerosis?
《Neural Regeneration Research》2021年第9期1715-1722,共8页Viviana Nociti Massimo Santoro 
Multiple sclerosis is a chronic, inflammatory and degenerative disease of the central nervous system of unknown aetiology although well-defined evidence supports an autoimmune pathogenesis. So far, the exact mechanism...
关键词：antisense lncRNAs enhancer lncRNAs EPIGENETICS immune system intergenic lncRNA intronic lncRNA multiple sclerosis sense lncRNAs single nucleotide polymorphisms 
Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma
《World Journal of Clinical Cases》2021年第8期1785-1792,共8页Dimitra Ioanna Lampropoulou Konstantinos Laschos Gerasimos Aravantinos Konstantinos Georgiou Konstantinos Papiris George Theodoropoulos Maria Gazouli Dimitrios Filippou 
The Hellenic Society of Medical Oncology,No.8021/25.09.2020.
BACKGROUND Cholangiocarcinoma(CCA)represents a rare but highly aggressive malignancy that is often challenging to diagnose,especially in early stages.The role of existing tumor biomarkers for CCA diagnosis,remains con...
关键词：CHOLANGIOCARCINOMA Homeobox protein transcript antisense intergenic ribonucleic acid polymorphisms Rs920778 Rs4759314 Rs7958904 
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