Association between homeobox protein transcript antisense intergenic ribonucleic acid genetic polymorphisms and cholangiocarcinoma  

作　　者：Dimitra Ioanna Lampropoulou Konstantinos Laschos Gerasimos Aravantinos Konstantinos Georgiou Konstantinos Papiris George Theodoropoulos Maria Gazouli Dimitrios Filippou 

机构地区：[1]Medical Oncology,General Oncology Hospital of Kifissia“Agioi Anargiroi”,Athens 14564,Greece [2]1st Department of Propaedeutic Surgery,Hippokration General Hospital of Athens,Athens Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece [3]Endoscopic Surgery Department,Hippokration General Hospital,Athens 11527,Greece [4]Basic Medical Sciences,Athens Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece [5]Anatomy and Surgical Anatomy,Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece

出　　处：《World Journal of Clinical Cases》2021年第8期1785-1792,共8页世界临床病例杂志

基　　金：The Hellenic Society of Medical Oncology,No.8021/25.09.2020.

摘　　要：BACKGROUND Cholangiocarcinoma(CCA)represents a rare but highly aggressive malignancy that is often challenging to diagnose,especially in early stages.The role of existing tumor biomarkers for CCA diagnosis,remains controversial due to their low sensitivity and specificity.Increasing evidence has implicated long non-coding ribonucleic acid polymorphisms with cancer susceptibility in a variety of tumor types.The association between long non-coding ribonucleic acid homeobox protein transcript antisense intergenic ribonucleic acid(HOTAIR)polymorphisms and CCA risk has not been reported yet.AIM To investigate the influence of HOTAIR variants on the risk of CCA development.METHODS We conducted a case-control study in which three HOTAIR single nucleotide polymorphisms(rs920778,rs4759314 and rs7958904)were genotyped in a Greek cohort.Our study population included 122 CCA patients(80 males and 42 females)and 165 healthy controls.The polymorphisms under investigation were examined in peripheral blood samples.RESULTS HOTAIR rs4759314 AG and GG genotypes were associated with a significantly increased CCA risk[P=0.004,odds ratio:3.13;95%confidence interval:1.65-5.91 and P=0.005,odds ratio:12.31;95%confidence interval:1.48-101.87,respectively].However,no significant associations of HOTAIR rs920778,and rs7958904 were detected.Similarly,we found no significant associations between rs4759314 AA genotype and CCA susceptibility.CONCLUSION HOTAIR rs4759314 AG and GG genotypes may be implicated with CCA development and may serve as a potential diagnostic biomarker.

关 键 词：CHOLANGIOCARCINOMA Homeobox protein transcript antisense intergenic ribonucleic acid polymorphisms Rs920778 Rs4759314 Rs7958904 

分 类 号：R735.8[医药卫生—肿瘤]