复方楂金颗粒喷雾干燥工艺研究  

Studies on Drying Process of Compound Zhajin Particulates By Spray Drying Method

作　　者：向晶[1] 苏艳霞[1] 施军平[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学附属杭州第六医院,浙江杭州310014

出　　处：《中华中医药学刊》2011年第12期2682-2684,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药计划科技资助项目(2008JA009)

摘　　要：目的:对复方楂金颗粒剂的喷雾干燥工艺进行优化。方法:以含水量为指标,优选加入浸膏粉的辅料;采用正交设计法,以复方中含水率、得粉率和绿原酸含量作为指标,确定最佳工艺条件。结果:加入3%的微粉硅胶可以降低含水率,同时能较好地改善浸膏的粘壁情况;最佳工艺参数为进/出风温度190℃/95℃、进料速度80mL/h、浸膏相对密度1.065。结论:该工艺合理,为工业化生产提供了依据。Objective： To optimize the best process for spray drying of Zhajin Particulates. Methods：The excipients added with powder extract was optimized by water content; processing conditions were optimized by orthogonal experiment; moisture content, powder extraction rate and the content of chlorogenic acid were investigated. Results： Adding 3% silieiidoxydum to powder extract could reduce moisture content and improve adhering to the wall. The optimum parameters were as following： inlet/outlet air temperature 190℃/95 ℃ , feeding rate 80ml/h, relative density of powder extract 1. 065. Conclusion： This investigation is reasonable and can provide reference for mass production of Zhajin granules.

关 键 词：楂金颗粒 喷雾干燥 含水率 绿原酸 

分 类 号：R943[医药卫生—药剂学]