磁导向纳米磁微粒栓塞脑动静脉畸形的实验研究  

Magnetism-guided endovascular embolization of cerebral arteriovenous malformations by magnetic nanoparticles in pigs

作　　者：于耀宇[1] 李建[1] 李立宏[1] 曲友直[1] 于嘉[1] 邓建平[1] 赵振伟[1] 高国栋[1] 张文彬[2] 魏孟广[2] 

机构地区：[1]第四军医大学唐都医院神经外科,西安710038 [2]中国人民武装警察部队医学院附属医院神经外科,天津300162

出　　处：《中国临床神经外科杂志》2011年第12期735-737,共3页Chinese Journal of Clinical Neurosurgery

基　　金：国家自然科学基金(NO:30772220);天津市自然科学基金(NO:07JCYBJC10400)

摘　　要：目的探讨磁导向纳米磁微粒定向栓塞脑动静脉畸形(CAVM)的有效性和可靠性。方法将建立了CAVM模型的15头小猪随机分为3组:磁导向组(聚焦磁场导向,n=6),非磁导向组(无聚焦磁场导向,n=6)和对照组(不做任何处理n=3),前两组均采用纳米磁微粒栓塞CAVM。分别在栓塞后1周进行DSA和B超声检查,观察栓塞效果。结果磁导向组在栓塞1周后DSA显示,CAVM和引流静脉几乎全部消失。术后1周B超示引流静脉无血流,右侧颈静脉血栓形成;平均流速为0,与非磁导向组的(70.22±2.26)cm/s和对照组的(75.53±2.24)cm/s相比,差异显著(P<0.01)。结论实验证实在磁场作用下,纳米磁微粒可以有效地、可靠地靶向栓塞小猪的CAVM。这可能为临床治疗CAVM提供了新的途径和栓塞材料。Objective To explore the reliability and effectiveness of magnetism-guided endovascular embolization of the cerebral arteriovenous malformations （CAVM） by magnetic albumin nanopartieles （MAN）. Methods Fifteen pigs with CAVM established by Massoud method were divided into three groups, i.e. Magnetism-guided （with focusing magnetic field） group （n=6）, no magnetism-guided （without focusing magnetic field） group （n=6） and control （without any treatment） group （n=3）. CAVM were endovascularly embolized by MAN in the animals of both the magnetism-guided and no magnetism-guided groups. All the animals were examined by DSA and B ultrasound respectively a week after the embolization in order to assess the effect of the embolization on CAVM. Results DSA showed that CAVM were completely embolized in the magnetism-guided group and CAVM were unchanged in the no magnetism-guided group and control group. B ultrasound showed that the drainage veins of CAVM had no blood flowing in the magnetism-guided group. Conclusion CAVM in the pigs can be embolized successfully by the targeting-biodistribution MAN. It is suggested that targeting-biodistribution MAN may be clinically used for the endovaseular embolization of CAVM.

关 键 词：脑动静脉畸形 模型 纳米磁微粒 定向栓塞 小猪 

分 类 号：R743.4[医药卫生—神经病学与精神病学]