食管癌患者炎症因子水平与新辅助化疗疗效的关系分析  

Correlations between inflammation - related markers and clinical response to neoadjuvant chemotherapy in patients with esophageal carcinoma

作　　者：周宜勇[1] 

机构地区：[1]解放军第四五五医院全军胸部肿瘤中心,上海200052

出　　处：《临床外科杂志》2011年第11期763-765,共3页Journal of Clinical Surgery

摘　　要：目的本研究拟了解临床上反应机体炎症水平的指标与食管癌新辅助化疗敏感性的关系。方法收集患者化疗前基线水平的C-反应蛋白（CRP）、红细胞沉降率（ESR）和中性粒细胞水平和化疗一个疗程后中性粒细胞水平，了解这些指标与患者接受两个疗程新辅助化疗后的手术根治率和化疗有效率的关系。结果CRP和ESR均与化疗疗效（包括手术根治率和化疗有效率）显著相关（P〈0．05），而基线状态下的中性粒细胞水平与疗效无关（P〉0．05），但其在化疗一个疗程后的变化与临床疗效显著相关（P〈0．05）。CRP和ESR异常及中性粒细胞治疗后升高的患者疗效较差。结论临床常见的机体炎症因子可用于预测食管癌患者的新辅助化疗疗效，可帮助筛选敏感的患者。Objective Although neoadjuvant chemotherapy has been well accepted in the treatment of esophageal carcinoma, the clinical benefit can behardly predicted. To investigate the correlations between inflammation - related markers and the efficiency of neoadjuvant chemotherapy for esophageal carcinoma. Methods Baseline levels of C - reactive protein （CRP） , erythrocyte sedimentation rate （ESR） , and neutrophils counts before and after one course of chemotherapy were assessed. Their correlations with the curative rate of surgery and the response rate to chemotherapy after two courses of neoadjuvant chemotherapy were studied. Results Baseline CRP and ESR（P〈0.05） ,but not neutrophils（P 〉0.05） ,were correlated with chemotherapy efficiency （ including curative rate of surgery and response rate to chemotherapy）. The increase of neutrophils after one course was significantly associated with efficiency （ P 〈 0.05 ）. Patients with abnormal baseline CRP and ESR or neutrophils increased by over 20% after treatment had worse efficiency. Conclusion Some inflammation - related markers could help to predict clinical response to chemotherapy and screen the potentially sensitive patients.

关 键 词：食管癌 新辅助化疗 C-反应蛋白 红细胞沉降率 中性粒细胞 

分 类 号：R735.1[医药卫生—肿瘤]