帕金森病患者记忆监测与情景记忆的相关研究  

Correlation research on the memory monitoring and episodic memory of patients with Parkinson＇ s disease

作　　者：吕心怡[1] 汪凯[1] 陈先文[1] 程怀东[2] 谢丹丹[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]安徽医科大学第二附属医院肿瘤内科

出　　处：《中华神经科杂志》2011年第12期805-809,共5页Chinese Journal of Neurology

基　　金：国家自然科学基金资助项目（30870766,30670706）;国家“973”项目子课题资助项目（2005CB522800）

摘　　要：目的研究帕金森病患者（Parkinson’s disease，PD）对情景记忆监测情况，并进一步探讨PD患者情景记忆障碍的可能机制。方法建立情景记忆知晓感（feeling of knowing—episodicmemory，FOK-EM）判断的试验范式，对25例PD患者和25名年龄及教育程度相匹配的健康对照（HC）者进行研究。结果与HC组的FOK-EM的回忆率（39．67％±6．11％）、再认率（58．42％±7．50％）以及FOK判断准确率（0．61±0．22）比较，PD患者组FOK。的回忆率（19．33％±5．10％）、再认率（45．93％±7．82％）以及FOK判断准确率（-0．18±0．46）显著降低，差异均有统计学意义（t=-4．833，P〈0．01；t=-2．497，P〈0．05；t=-5．986，P〈0．01）；FOKⅧ的肯定判断／正确再认成绩（20．47％±10．78％）以及肯定判断／错误再认成绩（即高估，29．53％±5．62％）与HC组的肯定判断／正确再认成绩（39．47％±9．47％）以及肯定判断／错误再认成绩（即高估，13．90％±5．50％）之间差异有统计学意义（t=3．564，P〈0．05；t=2．306，P〈0．05），且Stroop效应与FOK。的肯定判断／错误再认成绩呈正相关（r=0．640，P〈0．01）。结论PD患者的情景记忆监测受损，表现为对自身再认能力的高估。这种记忆监测受损与执行功能的损害相关，提示此机制可能是导致PD患者情景记忆障碍的重要因素。Objective To investigate the episodic memory monitoring ability in patients with Parkinson＇ s disease （PD） and explore the mechanism of the episodic memory impairment. Method The feeling-of-knowing （FOK） paradigm were established and subsequently administered in 25 PD patients and 25 healthy control （HC） participants who were matched in age and educational level. Results Compared with healthy control group （FOK_EM recall 39. 67% ±6. 11% ; recognition 58.42% ±7.50% ; FOK accuracy 0. 61 ± 0. 22）, the episodic memory and its monitoring ability in PD patients were significantly impaired on the accuracy rate of FOK_EM recall （ 19. 33% ±.10% , t = -4. 833, P 〈0. 1 ） , recognition （45.93% ±7.82%, t = -2.497, P 〈0.05） and FOK accuracy（ -0.18 ±.46, t = - 5. 986, P 〈0.01）. Furthermore, the correct judgment and correct recognition of FOK_EM （20. 47% ± 10. 78% ） and the correct judgment and false recognition of FOK_EM （29. 53% ±5. 62% ） in the PD group were significantly higher than the HC group （the correct judgment and correct recognition of FOKEM ： 39.47% ±9.47% and the correct judgment and false recognition of FOKEM： 13. 90% ±.50%; t =3.564, P〈0.05 ; t =2.306, P〈 0.05）. Most importantly, the stroop effect was positively correlated with the correct judgment and false recognition of FOK_EM in PD group （ r = 0. 640, P 〈 0. 05 ）. Conclusions In the present study, the PD patients demonstrated an overestimation of their recognition ability of episodic memory, moreover, this impairment of memory monitoring was positively correlated with the deficit of executive function, indicating that this mechanism could be an influential factor of memory disorder in PD.

关 键 词：帕金森病 记忆 记忆障碍 认知 

分 类 号：R742.5[医药卫生—神经病学与精神病学]